Toll-like receptor 2 precursor - Macaca mulatta (Rhesus macaque)

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B3Y618 (TLR2_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 39. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Toll-like receptor 2

Alternative name(s):
CD_antigen=CD282

Gene names

Name:

TLR2

Organism

Macaca mulatta (Rhesus macaque) [Reference proteome]

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	784 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins By similarity.
Subunit structure	Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3. Interacts with ATG16L1 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Domain	Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12 By similarity. The ATG16L1-binding motif mediates interaction with ATG16L1 By similarity.
Sequence similarities	Belongs to the Toll-like receptor family. Contains 19 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 TIR domain.

Ontologies

Keywords
Biological process	Immunity Inflammatory response Innate immunity
Cellular component	Membrane
Domain	Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	MyD88-dependent toll-like receptor signaling pathway Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of inflammatory response Inferred from electronic annotation. Source: InterPro regulation of cytokine secretion Inferred from electronic annotation. Source: InterPro response to molecule of bacterial origin Inferred from electronic annotation. Source: InterPro toll-like receptor 2 signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transmembrane signaling receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

Potential

Chain

21 – 784

764

Toll-like receptor 2

PRO_0000363778

Regions

Topological domain

21 – 587

567

Extracellular Potential

Transmembrane

588 – 608

Helical; Potential

Topological domain

609 – 784

176

Cytoplasmic Potential

Repeat

54 – 77

LRR 1

Repeat

78 – 101

LRR 2

Repeat

102 – 125

LRR 3

Repeat

126 – 150

LRR 4

Repeat

151 – 175

LRR 5

Repeat

176 – 199

LRR 6

Repeat

200 – 223

LRR 7

Repeat

224 – 250

LRR 8

Repeat

251 – 278

LRR 9

Repeat

279 – 308

LRR 10

Repeat

309 – 337

LRR 11

Repeat

338 – 361

LRR 12

Repeat

362 – 388

LRR 13

Repeat

389 – 414

LRR 14

Repeat

415 – 437

LRR 15

Repeat

438 – 457

LRR 16

Repeat

458 – 478

LRR 17

Repeat

479 – 500

LRR 18

Repeat

501 – 524

LRR 19

Domain

525 – 579

LRRCT

Domain

639 – 784

146

TIR

Motif

761 – 778

ATG16L1-binding motif

Sites

Site

349

Interaction with bacterial lipopeptide By similarity

Amino acid modifications

Glycosylation

114

N-linked (GlcNAc...) Potential

Glycosylation

199

N-linked (GlcNAc...) Potential

Glycosylation

414

N-linked (GlcNAc...) Potential

Glycosylation

442

N-linked (GlcNAc...) Potential

Disulfide bond

30 ↔ 36

By similarity

Disulfide bond

353 ↔ 382

By similarity

Disulfide bond

432 ↔ 454

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

B3Y618 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: DB9540DD390BF91D
Show »

FASTA

784

90,071

        10         20         30         40         50         60 
MPHTLWMVWV LGVIISLSKE ESSNQASLSC DHNGICKGSS GSLNSIPSVL TEAVKCLDLS 

        70         80         90        100        110        120 
NNRITYISNS DLQRYVNLQA LVLTSNGINT IEEDSFSSLG RLEHLDLSYN YLSNLSSSWF 

       130        140        150        160        170        180 
KPLSSLKFLN LLGNPYKTLG ETSLFSHLTK LRILRVGNMD TFTKIQRKDF AGLTFLEELE 

       190        200        210        220        230        240 
IDASDLQSYE PKSLKSIQNV SHLILHMKQH ILLLEIFVDL TSSVECLELR DTDLNTFHFS 

       250        260        270        280        290        300 
ELSTGETNSL IKKFTFRNVK ITDESLFQVM KLLSQISGLL ELEFDDCTLN GVGDFRGSDN 

       310        320        330        340        350        360 
DRVIDPGKVE TLTIRRLHIP QFYSFNDLST LYPLTERVKR ITVENSKVFL VPCLLSRHLK 

       370        380        390        400        410        420 
SLEYLDLSEN LMVEEYLKNS ACEDAWPSLQ TLILRQNHLA SLGKIGETLL TLKNLTNLDI 

       430        440        450        460        470        480 
SKNTFHYMPE TCQWPEKMKY LNLSSTRIHS VTGCIPKTLE ILDISNNNLN LFSLNLPQLK 

       490        500        510        520        530        540 
ELYISRNKLM TLPDASLLPM LLVLKISRNT ITTFSKEQLD SFHTLKTLEA GGNNFICSCE 

       550        560        570        580        590        600 
FLSFTQEQQA LAKVLVDWPA NYLCDSPSHV RGQRVQDVRL SVSECHRAAL VSGMCCALFL 

       610        620        630        640        650        660 
LILLMGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPNRDIC YDAFVSYSER DAYWVENLMV 

       670        680        690        700        710        720 
QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV FVLSENFVKS EWCKYELDFS 

       730        740        750        760        770        780 
HFRLFDENND AAILVLLEPI EKKAIPQRFC KLRKIMNTKT YLEWPMDEAR QEGFWVNLRA 


AIKS

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References

[1]	"Molecular evolution of the Toll-like receptor-related genes in primates." Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB445630 mRNA. Translation: BAG55027.1.
RefSeq	NP_001123897.1. NM_001130425.1.
UniGene	Mmu.3812.
3D structure databases
ProteinModelPortal	B3Y618.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	574290.
KEGG	mcc:574290.
Organism-specific databases
CTD	7097.
Phylogenomic databases
eggNOG	NOG251801.
HOGENOM	HOG000110611.
HOVERGEN	HBG108574.
KO	K10159.
OrthoDB	EOG4SN1N6.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000157. TIR_dom. IPR027185. TLR2. IPR017241. Toll-like_receptor. [Graphical view]
PANTHER	PTHR24365:SF17. PTHR24365:SF17. 1 hit.
Pfam	PF01582. TIR. 1 hit. [Graphical view]
PIRSF	PIRSF037595. Toll-like_receptor. 1 hit.
SMART	SM00369. LRR_TYP. 2 hits. SM00082. LRRCT. 1 hit. SM00255. TIR. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS51450. LRR. 11 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	19986524.

Entry information

Entry name

TLR2_MACMU

Accession

Primary (citable) accession number: B3Y618

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents