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B3Y613 (TLR2_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Toll-like receptor 2
Alternative name(s):
CD_antigen=CD282
Gene names
Name:TLR2
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length784 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins By similarity.

Subunit structure

Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3. Interacts with ATG16L1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Domain

Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12 By similarity.

The ATG16L1-binding motif mediates interaction with ATG16L1 By similarity.

Sequence similarities

Belongs to the Toll-like receptor family.

Contains 19 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 TIR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 784764Toll-like receptor 2
PRO_0000363777

Regions

Topological domain21 – 587567Extracellular Potential
Transmembrane588 – 60821Helical; Potential
Topological domain609 – 784176Cytoplasmic Potential
Repeat54 – 7724LRR 1
Repeat78 – 10124LRR 2
Repeat102 – 12524LRR 3
Repeat126 – 15025LRR 4
Repeat151 – 17525LRR 5
Repeat176 – 19924LRR 6
Repeat200 – 22324LRR 7
Repeat224 – 25027LRR 8
Repeat251 – 27828LRR 9
Repeat279 – 30830LRR 10
Repeat309 – 33729LRR 11
Repeat338 – 36124LRR 12
Repeat362 – 38827LRR 13
Repeat389 – 41426LRR 14
Repeat415 – 43723LRR 15
Repeat438 – 45720LRR 16
Repeat458 – 47821LRR 17
Repeat479 – 50022LRR 18
Repeat501 – 52424LRR 19
Domain525 – 57955LRRCT
Domain639 – 784146TIR
Motif761 – 77818ATG16L1-binding motif

Sites

Site3491Interaction with bacterial lipopeptide By similarity

Amino acid modifications

Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation4141N-linked (GlcNAc...) Potential
Glycosylation4421N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 36 By similarity
Disulfide bond353 ↔ 382 By similarity
Disulfide bond432 ↔ 454 By similarity

Sequences

Sequence LengthMass (Da)Tools
B3Y613 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 9F46005D894F7CB5

FASTA78489,825
        10         20         30         40         50         60 
MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSIPSGL TEAVKSLDLS 

        70         80         90        100        110        120 
NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG SLEHLDLSYN YLSNLSSSWF 

       130        140        150        160        170        180 
KPLSSLTFLN LLGNPYKTLG ETSLFSHLTK LQILRVGNMD TFTKIQRKDF AGLTFLEELE 

       190        200        210        220        230        240 
IDASDLQSYE PKSLKSIQNV SHLILHMKQH ILLLEIFVDV TSSVECLELR DTDLDTFRFS 

       250        260        270        280        290        300 
ELSTGETNSL IKKFTFRNVK ITDESLFQVM KLLNQISGLL ELEFDDCTLN GVGNFRASDN 

       310        320        330        340        350        360 
DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERVKR ITVENSKVFL VPCLLSQHLK 

       370        380        390        400        410        420 
SLEYLDLSEN LIVEEYLKNS ACEDAWPSLQ TLILRQNHLA SLEKTGETLL TLKNLTNVDI 

       430        440        450        460        470        480 
SKNSFHSMPE TCQWPEKMKY LNLSSTRIHS VTGCIPKTLE ILDVSNNNLN LFSLNLPQLK 

       490        500        510        520        530        540 
ELYISRNKLM TLPDASLLPM LLVLKISRNA ITTFSKEQLD SFHTLKTLEA GGNNFICSCE 

       550        560        570        580        590        600 
FLSFTQEQQA LAKVLIDWPA NYLCDSPSHV RGQQVQDVRL SVSECHRTAL VSGMCCALFL 

       610        620        630        640        650        660 
LILLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPSRNIC YDAFVSYSER DAYWVENLMV 

       670        680        690        700        710        720 
QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV FVLSENFVKS EWCKYELDFS 

       730        740        750        760        770        780 
HFRLFDENND AAILILLEPI EKKAIPQRFC KLRKIMNTKT YLEWPMDEAQ REGFWVNLRA 


AIKS 

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References

[1]"Molecular evolution of the Toll-like receptor-related genes in primates."
Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB445625 mRNA. Translation: BAG55022.1.
RefSeqNP_001123941.1. NM_001130469.1.
UniGenePtr.3835.

3D structure databases

ProteinModelPortalB3Y613.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9598.ENSPTRP00000028379.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID471325.
KEGGptr:471325.

Organism-specific databases

CTD7097.

Phylogenomic databases

eggNOGNOG251801.
HOGENOMHOG000110611.
HOVERGENHBG108574.
KOK10159.

Family and domain databases

Gene3D3.40.50.10140. 1 hit.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERPTHR24365:SF175. PTHR24365:SF175. 1 hit.
PfamPF01582. TIR. 1 hit.
[Graphical view]
PIRSFPIRSF037595. Toll-like_receptor. 1 hit.
SMARTSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. SSF52200. 1 hit.
PROSITEPS51450. LRR. 11 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20848302.

Entry information

Entry nameTLR2_PANTR
AccessionPrimary (citable) accession number: B3Y613
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families