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B3Y613

- TLR2_PANTR

UniProt

B3Y613 - TLR2_PANTR

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Protein

Toll-like receptor 2

Gene
TLR2
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei349 – 3491Interaction with bacterial lipopeptide By similarity

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. inflammatory response Source: UniProtKB-KW
  2. innate immune response Source: UniProtKB-KW
  3. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  4. positive regulation of inflammatory response Source: InterPro
  5. regulation of cytokine secretion Source: InterPro
  6. response to molecule of bacterial origin Source: InterPro
  7. toll-like receptor 2 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 2
Alternative name(s):
CD_antigen: CD282
Gene namesi
Name:TLR2
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 587567Extracellular Reviewed predictionAdd
BLAST
Transmembranei588 – 60821Helical; Reviewed predictionAdd
BLAST
Topological domaini609 – 784176Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 784764Toll-like receptor 2PRO_0000363777Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 36 By similarity
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi199 – 1991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi353 ↔ 382 By similarity
Glycosylationi414 – 4141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi432 ↔ 454 By similarity
Glycosylationi442 – 4421N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3. Interacts with ATG16L1 By similarity.

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000028379.

Structurei

3D structure databases

ProteinModelPortaliB3Y613.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 7724LRR 1Add
BLAST
Repeati78 – 10124LRR 2Add
BLAST
Repeati102 – 12524LRR 3Add
BLAST
Repeati126 – 15025LRR 4Add
BLAST
Repeati151 – 17525LRR 5Add
BLAST
Repeati176 – 19924LRR 6Add
BLAST
Repeati200 – 22324LRR 7Add
BLAST
Repeati224 – 25027LRR 8Add
BLAST
Repeati251 – 27828LRR 9Add
BLAST
Repeati279 – 30830LRR 10Add
BLAST
Repeati309 – 33729LRR 11Add
BLAST
Repeati338 – 36124LRR 12Add
BLAST
Repeati362 – 38827LRR 13Add
BLAST
Repeati389 – 41426LRR 14Add
BLAST
Repeati415 – 43723LRR 15Add
BLAST
Repeati438 – 45720LRR 16Add
BLAST
Repeati458 – 47821LRR 17Add
BLAST
Repeati479 – 50022LRR 18Add
BLAST
Repeati501 – 52424LRR 19Add
BLAST
Domaini525 – 57955LRRCTAdd
BLAST
Domaini639 – 784146TIRAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi761 – 77818ATG16L1-binding motifAdd
BLAST

Domaini

Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12 By similarity.
The ATG16L1-binding motif mediates interaction with ATG16L1 By similarity.

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 TIR domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251801.
HOGENOMiHOG000110611.
HOVERGENiHBG108574.
KOiK10159.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF17. PTHR24365:SF17. 1 hit.
PfamiPF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3Y613-1 [UniParc]FASTAAdd to Basket

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MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSIPSGL    50
TEAVKSLDLS NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG 100
SLEHLDLSYN YLSNLSSSWF KPLSSLTFLN LLGNPYKTLG ETSLFSHLTK 150
LQILRVGNMD TFTKIQRKDF AGLTFLEELE IDASDLQSYE PKSLKSIQNV 200
SHLILHMKQH ILLLEIFVDV TSSVECLELR DTDLDTFRFS ELSTGETNSL 250
IKKFTFRNVK ITDESLFQVM KLLNQISGLL ELEFDDCTLN GVGNFRASDN 300
DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERVKR ITVENSKVFL 350
VPCLLSQHLK SLEYLDLSEN LIVEEYLKNS ACEDAWPSLQ TLILRQNHLA 400
SLEKTGETLL TLKNLTNVDI SKNSFHSMPE TCQWPEKMKY LNLSSTRIHS 450
VTGCIPKTLE ILDVSNNNLN LFSLNLPQLK ELYISRNKLM TLPDASLLPM 500
LLVLKISRNA ITTFSKEQLD SFHTLKTLEA GGNNFICSCE FLSFTQEQQA 550
LAKVLIDWPA NYLCDSPSHV RGQQVQDVRL SVSECHRTAL VSGMCCALFL 600
LILLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPSRNIC YDAFVSYSER 650
DAYWVENLMV QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV 700
FVLSENFVKS EWCKYELDFS HFRLFDENND AAILILLEPI EKKAIPQRFC 750
KLRKIMNTKT YLEWPMDEAQ REGFWVNLRA AIKS 784
Length:784
Mass (Da):89,825
Last modified:September 23, 2008 - v1
Checksum:i9F46005D894F7CB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB445625 mRNA. Translation: BAG55022.1.
RefSeqiNP_001123941.1. NM_001130469.1.
UniGeneiPtr.3835.

Genome annotation databases

GeneIDi471325.
KEGGiptr:471325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB445625 mRNA. Translation: BAG55022.1 .
RefSeqi NP_001123941.1. NM_001130469.1.
UniGenei Ptr.3835.

3D structure databases

ProteinModelPortali B3Y613.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000028379.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 471325.
KEGGi ptr:471325.

Organism-specific databases

CTDi 7097.

Phylogenomic databases

eggNOGi NOG251801.
HOGENOMi HOG000110611.
HOVERGENi HBG108574.
KOi K10159.

Miscellaneous databases

NextBioi 20848302.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view ]
PANTHERi PTHR24365:SF17. PTHR24365:SF17. 1 hit.
Pfami PF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view ]
PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
SMARTi SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 11 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular evolution of the Toll-like receptor-related genes in primates."
    Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTLR2_PANTR
AccessioniPrimary (citable) accession number: B3Y613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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