B3X801 (B3X801_ECOLX) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
EC=1.1.1.17 HAMAP MF_00196

Gene names

Name:	mtlD HAMAP MF_00196 EMBL EDX41226.1
ORF Names:	EC1011_4889 EMBL EDX41226.1

Organism

Escherichia coli 101-1 EMBL EDX41226.1

Taxonomic identifier

358709 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196 SAAS SAAS000669
Sequence similarities	Belongs to the mannitol dehydrogenase family. HAMAP MF_00196

Ontologies

Keywords
Ligand	NAD HAMAP MF_00196 SAAS SAAS000669
Molecular function	Oxidoreductase HAMAP MF_00196 SAAS SAAS023028 EMBL EDX41226.1
PTM	Acetylation HAMAP MF_00196
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity HAMAP MF_00196
Amino acid modifications
	Modified residue	269	1	N6-acetyllysine By similarity HAMAP MF_00196

Sequences

	Sequence		Length	Mass (Da)
	B3X801 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 3121F924FE9357B7	FASTA	382	41,124
	10 20 30 40 50 60 MKALHFGAGN IGRGFIGKLL ADAGIQLTFA DVNQVVLDAL NARHSYQVHV VGETEQVDTV 70 80 90 100 110 120 SGVNAVSSIG DDVVDLIAQV DLVTTAVGPV VLERIAPAIA KGLVKRKEQG NESPLNIIAC 130 140 150 160 170 180 ENMVRGTTQL KGHVMNALPE DAKAWVEEHV GFVDSAVDRI VPPSASATND PLEVTVETFS 190 200 210 220 230 240 EWIVDKTQFK GALPNIPGME LTDNLMAFVE RKLFTLNTGH AITAYLGKLA GHQTIRDAIL 250 260 270 280 290 300 DEKIRAVVKG AMEESGAVLI KRYGFDADKH AAYIQKILGR FENPYLKDDV ERVGRQPLRK 310 320 330 340 350 360 LSAGDRLIKP LLGTLEYGLP HKNLIEGIAA AMHFRSEDDP QAQELAALIA DKGPQAALAQ 370 380 ISGLDANSEV VSEAVTAYKA MQ

References

[1]	Rasko D.A., Rosovitz M.J., Nataro J.P., Myers G.S.A., Sheshadri R., Cer R.Z., Jiang L., Ravel J. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 101-1 EMBL EDX41226.1.
[2]	Rasko D., Rosovitz M., Myers G., Seshadri R., Cer R., Jiang L., Ravel J., Fricke W.F., Sebastian Y. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 101-1 EMBL EDX41226.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAMK02000001 Genomic DNA. Translation: EDX41226.1.
3D structure databases
ProteinModelPortal	B3X801.
SMR	B3X801. Positions 1-382.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	30335283. VBIEscCol127656_0192.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR023027. Mannitol_DH_CS. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B3X801_ECOLX

Accession

Primary (citable) accession number: B3X801

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)