B3WTU9 (B3WTU9_ECOLX) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase HAMAP MF_01657
EC=1.2.1.10 HAMAP MF_01657

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] HAMAP MF_01657

Gene names

Name:	mhpF HAMAP MF_01657 EMBL EDX27957.1
ORF Names:	EcB171_4888 EMBL EDX27957.1

Organism

Escherichia coli B171 EMBL EDX27957.1

Taxonomic identifier

344601 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657 SAAS SAAS015426
Pathway	Aromatic compound metabolism; 3-phenylpropanoate degradation. HAMAP MF_01657
Subunit structure	Interacts with MhpE By similarity. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family. HAMAP MF_01657

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism HAMAP MF_01657 SAAS SAAS015426
Ligand	NAD HAMAP MF_01657 SAAS SAAS015426
Molecular function	Oxidoreductase HAMAP MF_01657 SAAS SAAS015426 EMBL EDX27957.1
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: HAMAP acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	11 – 14	4	NAD By similarity HAMAP MF_01657
	Nucleotide binding	162 – 170	9	NAD By similarity HAMAP MF_01657
Sites
	Binding site	289	1	NAD By similarity HAMAP MF_01657

Sequences

	Sequence		Length	Mass (Da)
	B3WTU9 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: A6918BDA5EF4876B	FASTA	316	33,442
	10 20 30 40 50 60 MSKRKVAIIG SGNIGTDLMI KILRHGQHLE MAVMVGIDPQ SDGLARARRM GVATTHEGVI 70 80 90 100 110 120 GLMNMPEFAD IDIVFDATSA GAHVKNDAAL REAKPDIRLI DLTPAAIGPY CVPVVNLEAN 130 140 150 160 170 180 VDQLNVNMVT CGGQATIPMV AAVSRVARVH YAEIIASIAS KSAGPGTRAN IDEFTETTSR 190 200 210 220 230 240 AIEVVGGAAK GKAIIVLNPA EPPLMMRDTV YVLSDEASQD DIEASINEMA EAVQAYVPGY 250 260 270 280 290 300 RLKQRVQFEV IPQDKPVNLP GVGQFSGLKT AVWLEVEGAA HYLPAYAGNL DIMTSSALAT 310 AEKMAQSLAR KAGEAA

References

[1]	Rasko D.A., Rosovitz M.J., Kaper J.B., Myers G.S.A., Sheshadri R., Cer R.Z., Jiang L., Ravel J. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: B171 EMBL EDX27957.1.
[2]	Rasko D., Rosovitz M., Myers G., Seshadri R., Cer R., Jiang L., Ravel J., Fricke W.F., Sebastian Y. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: B171 EMBL EDX27957.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAJX02000065 Genomic DNA. Translation: EDX27957.1.
3D structure databases
ProteinModelPortal	B3WTU9.
SMR	B3WTU9. Positions 3-308.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	31237328. VBIEscCol100091_4922.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B3WTU9_ECOLX

Accession

Primary (citable) accession number: B3WTU9

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)