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B3WF93

- PUR9_LACCB

UniProt

B3WF93 - PUR9_LACCB

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Lactobacillus casei (strain BL23)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciLCAS543734:GCHL-1942-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:LCABL_19660
    OrganismiLactobacillus casei (strain BL23)
    Taxonomic identifieri543734 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001206: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Bifunctional purine biosynthesis protein PurHPRO_1000096068Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi543734.LCABL_19660.

    Structurei

    3D structure databases

    ProteinModelPortaliB3WF93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3WF93-1 [UniParc]FASTAAdd to Basket

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    MKRALLSVSD KTGLVSFAKG LIDRGFELVS TGGTHRELAA AGIAVTSVEE    50
    VTGFPEMLDG RVKTLHPKIH AGILARRDDP DHMEALANHD IQPVDLVCVN 100
    LYPFAATIKR PDVTRAEAIE QIDIGGPSAL RAAAKNSDSV WAVVDPADYE 150
    AVLTGLDQDD AHLRQKLAAK VFAITAAYDA QIVHYLDPEP FPEHFTPTYT 200
    KRQDLRYGEN SHQQAAFYVE PDPNPTSLAA AKQLHGKELS YNNIKDADAA 250
    LAMLREFSEP AVVAVKHMNP CGIGLGKTIE GAWDKAYAAD PMSIFGGIIA 300
    LNRPVDLATA EKMHKLFLEI IIAPAFDDDA YAVLAKKKNV RLLTINTADT 350
    PAELGTETTA IYGGLLIQTR DNQTETPADM TVVTTVKPTD EQLKALAFAQ 400
    TVVKHVKSNA IVVAQADQTL GIGAGQMNRI GSVELALTQA QQNDNFAGAV 450
    MASDAFFPMD DCVDYAAKHD IKAIIQPGGS IRDKDSIEKA NQYGIAMVTT 500
    GVRHFRH 507
    Length:507
    Mass (Da):54,772
    Last modified:September 2, 2008 - v1
    Checksum:i0325731AA91558D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM177140 Genomic DNA. Translation: CAQ67044.1.
    RefSeqiYP_001987902.1. NC_010999.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ67044; CAQ67044; LCABL_19660.
    GeneIDi6406624.
    KEGGilcb:LCABL_19660.
    PATRICi22213371. VBILacCas89204_1869.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM177140 Genomic DNA. Translation: CAQ67044.1 .
    RefSeqi YP_001987902.1. NC_010999.1.

    3D structure databases

    ProteinModelPortali B3WF93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 543734.LCABL_19660.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ67044 ; CAQ67044 ; LCABL_19660 .
    GeneIDi 6406624.
    KEGGi lcb:LCABL_19660.
    PATRICi 22213371. VBILacCas89204_1869.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci LCAS543734:GCHL-1942-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Lactobacillus casei BL23 complete genome sequence."
      Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BL23.

    Entry informationi

    Entry nameiPUR9_LACCB
    AccessioniPrimary (citable) accession number: B3WF93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3