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B3WF93

- PUR9_LACCB

UniProt

B3WF93 - PUR9_LACCB

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, LCABL_19660
Organism
Lactobacillus casei (strain BL23)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciLCAS543734:GCHL-1942-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:LCABL_19660
OrganismiLactobacillus casei (strain BL23)
Taxonomic identifieri543734 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001206: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000096068Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi543734.LCABL_19660.

Structurei

3D structure databases

ProteinModelPortaliB3WF93.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B3WF93-1 [UniParc]FASTAAdd to Basket

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MKRALLSVSD KTGLVSFAKG LIDRGFELVS TGGTHRELAA AGIAVTSVEE    50
VTGFPEMLDG RVKTLHPKIH AGILARRDDP DHMEALANHD IQPVDLVCVN 100
LYPFAATIKR PDVTRAEAIE QIDIGGPSAL RAAAKNSDSV WAVVDPADYE 150
AVLTGLDQDD AHLRQKLAAK VFAITAAYDA QIVHYLDPEP FPEHFTPTYT 200
KRQDLRYGEN SHQQAAFYVE PDPNPTSLAA AKQLHGKELS YNNIKDADAA 250
LAMLREFSEP AVVAVKHMNP CGIGLGKTIE GAWDKAYAAD PMSIFGGIIA 300
LNRPVDLATA EKMHKLFLEI IIAPAFDDDA YAVLAKKKNV RLLTINTADT 350
PAELGTETTA IYGGLLIQTR DNQTETPADM TVVTTVKPTD EQLKALAFAQ 400
TVVKHVKSNA IVVAQADQTL GIGAGQMNRI GSVELALTQA QQNDNFAGAV 450
MASDAFFPMD DCVDYAAKHD IKAIIQPGGS IRDKDSIEKA NQYGIAMVTT 500
GVRHFRH 507
Length:507
Mass (Da):54,772
Last modified:September 2, 2008 - v1
Checksum:i0325731AA91558D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM177140 Genomic DNA. Translation: CAQ67044.1.
RefSeqiYP_001987902.1. NC_010999.1.

Genome annotation databases

EnsemblBacteriaiCAQ67044; CAQ67044; LCABL_19660.
GeneIDi6406624.
KEGGilcb:LCABL_19660.
PATRICi22213371. VBILacCas89204_1869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM177140 Genomic DNA. Translation: CAQ67044.1 .
RefSeqi YP_001987902.1. NC_010999.1.

3D structure databases

ProteinModelPortali B3WF93.
ModBasei Search...

Protein-protein interaction databases

STRINGi 543734.LCABL_19660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ67044 ; CAQ67044 ; LCABL_19660 .
GeneIDi 6406624.
KEGGi lcb:LCABL_19660.
PATRICi 22213371. VBILacCas89204_1869.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci LCAS543734:GCHL-1942-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Lactobacillus casei BL23 complete genome sequence."
    Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BL23.

Entry informationi

Entry nameiPUR9_LACCB
AccessioniPrimary (citable) accession number: B3WF93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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