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B3WER5

- IF2_LACCB

UniProt

B3WER5 - IF2_LACCB

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Protein
Translation initiation factor IF-2
Gene
infB, LCABL_17860
Organism
Lactobacillus casei (strain BL23)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi453 – 4608GTP By similarity
Nucleotide bindingi499 – 5035GTP By similarity
Nucleotide bindingi553 – 5564GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCAS543734:GCHL-1763-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:LCABL_17860
OrganismiLactobacillus casei (strain BL23)
Taxonomic identifieri543734 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001206: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 943943Translation initiation factor IF-2UniRule annotation
PRO_1000093796Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi543734.LCABL_17860.

Structurei

3D structure databases

ProteinModelPortaliB3WER5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini444 – 613170tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni453 – 4608G1 By similarity
Regioni478 – 4825G2 By similarity
Regioni499 – 5024G3 By similarity
Regioni553 – 5564G4 By similarity
Regioni589 – 5913G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiRSANNAN.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3WER5-1 [UniParc]FASTAAdd to Basket

« Hide

MGKKRVYEFA KEMHVDNKDV IDIAKNLGIE VKNHMSSIDQ DQEAKIKGML    50
SKQSAGKAPS SQAAKTPAKA AKTSSAAHKE AAKKPVAASA KSNDHADVAE 100
HSQKNAKPAA KQENKPARSN KTSDGKIILS KSTILRPRST QTAHTNTNHN 150
RGGNTASANN TANGRNSNRS NNNNNNRSAN NANRSGNNNR SNERNRNDRN 200
RRFDNQRVTG PMPRAGRPTA ANGNPRPVAG NGGKFVKPAS ERQQPKRQEA 250
VKPANAASKR SEQPRTERPR TEQPAATTNQ RFTKPAPVPA AAAPKPASAG 300
SQDNRNSRRG GGNSNFGRSN SYGNRNGFNR NNRRNKKNKR RQQSAPKKEM 350
PQRKERPLPE TLIYEVGMNA QDLGKILHRE PAELIKKLFM LGVMVNQNQS 400
LDKDTIELLA TDYGIDAQEK VHEDISDLDK VFEEENKNQD NLQPRPPVVT 450
IMGHVDHGKT TLLDKLRHTH VTEGEAGGIT QHIGAYQVKL RDRLITFLDT 500
PGHAAFTNMR ARGADITDIV VLVVAADDGV MPQTIEAIHH AQAAKAPIIV 550
AVNKIDKPGA NPDHVMEQLT EYGLIPEDWG GDTIFVKISA KFGKNIDELL 600
EMILLEADVL ELKANPDQKA VGTVIEARLD KGKGPVATVL VQQGTLHTGD 650
PIVVGNTFGR VRAMTNDHGR RVKDALPSMP VEITGINDVP QSADKFVVFA 700
DERTARAAGE ERAKRAQEEE RKNTNHVTLD NLFETMKEGQ LKEVDVIIKA 750
DVQGSVEALA GSLEKIEVKG VRVNIIHQAV GAINESDVTL AAASNAIIIG 800
FNVRPTALAK AQAEQDDVDI RLHSVIYKAI EEVEAAMKGM LEPTYEEKVI 850
GTVTVRETIP VSKVGTVVGG YVDSGYITRD AGVRLVRDGI VKYEGKLGSL 900
RRFKDDVKEV RQGFELGLTI ENYNDIKVDD QIEAFTMEQV PVK 943
Length:943
Mass (Da):103,151
Last modified:September 2, 2008 - v1
Checksum:i01B5958EAC6C5C54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM177140 Genomic DNA. Translation: CAQ66866.1.
RefSeqiYP_001987724.1. NC_010999.1.

Genome annotation databases

EnsemblBacteriaiCAQ66866; CAQ66866; LCABL_17860.
GeneIDi6406655.
KEGGilcb:LCABL_17860.
PATRICi22213015. VBILacCas89204_1693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM177140 Genomic DNA. Translation: CAQ66866.1 .
RefSeqi YP_001987724.1. NC_010999.1.

3D structure databases

ProteinModelPortali B3WER5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 543734.LCABL_17860.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ66866 ; CAQ66866 ; LCABL_17860 .
GeneIDi 6406655.
KEGGi lcb:LCABL_17860.
PATRICi 22213015. VBILacCas89204_1693.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi RSANNAN.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci LCAS543734:GCHL-1763-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Lactobacillus casei BL23 complete genome sequence."
    Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BL23.

Entry informationi

Entry nameiIF2_LACCB
AccessioniPrimary (citable) accession number: B3WER5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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