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B3WER5

- IF2_LACCB

UniProt

B3WER5 - IF2_LACCB

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Lactobacillus casei (strain BL23)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi453 – 4608GTPUniRule annotation
    Nucleotide bindingi499 – 5035GTPUniRule annotation
    Nucleotide bindingi553 – 5564GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLCAS543734:GCHL-1763-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:LCABL_17860
    OrganismiLactobacillus casei (strain BL23)
    Taxonomic identifieri543734 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001206: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 943943Translation initiation factor IF-2PRO_1000093796Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi543734.LCABL_17860.

    Structurei

    3D structure databases

    ProteinModelPortaliB3WER5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini444 – 613170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni453 – 4608G1By similarity
    Regioni478 – 4825G2By similarity
    Regioni499 – 5024G3By similarity
    Regioni553 – 5564G4By similarity
    Regioni589 – 5913G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiRSANNAN.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3WER5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKKRVYEFA KEMHVDNKDV IDIAKNLGIE VKNHMSSIDQ DQEAKIKGML    50
    SKQSAGKAPS SQAAKTPAKA AKTSSAAHKE AAKKPVAASA KSNDHADVAE 100
    HSQKNAKPAA KQENKPARSN KTSDGKIILS KSTILRPRST QTAHTNTNHN 150
    RGGNTASANN TANGRNSNRS NNNNNNRSAN NANRSGNNNR SNERNRNDRN 200
    RRFDNQRVTG PMPRAGRPTA ANGNPRPVAG NGGKFVKPAS ERQQPKRQEA 250
    VKPANAASKR SEQPRTERPR TEQPAATTNQ RFTKPAPVPA AAAPKPASAG 300
    SQDNRNSRRG GGNSNFGRSN SYGNRNGFNR NNRRNKKNKR RQQSAPKKEM 350
    PQRKERPLPE TLIYEVGMNA QDLGKILHRE PAELIKKLFM LGVMVNQNQS 400
    LDKDTIELLA TDYGIDAQEK VHEDISDLDK VFEEENKNQD NLQPRPPVVT 450
    IMGHVDHGKT TLLDKLRHTH VTEGEAGGIT QHIGAYQVKL RDRLITFLDT 500
    PGHAAFTNMR ARGADITDIV VLVVAADDGV MPQTIEAIHH AQAAKAPIIV 550
    AVNKIDKPGA NPDHVMEQLT EYGLIPEDWG GDTIFVKISA KFGKNIDELL 600
    EMILLEADVL ELKANPDQKA VGTVIEARLD KGKGPVATVL VQQGTLHTGD 650
    PIVVGNTFGR VRAMTNDHGR RVKDALPSMP VEITGINDVP QSADKFVVFA 700
    DERTARAAGE ERAKRAQEEE RKNTNHVTLD NLFETMKEGQ LKEVDVIIKA 750
    DVQGSVEALA GSLEKIEVKG VRVNIIHQAV GAINESDVTL AAASNAIIIG 800
    FNVRPTALAK AQAEQDDVDI RLHSVIYKAI EEVEAAMKGM LEPTYEEKVI 850
    GTVTVRETIP VSKVGTVVGG YVDSGYITRD AGVRLVRDGI VKYEGKLGSL 900
    RRFKDDVKEV RQGFELGLTI ENYNDIKVDD QIEAFTMEQV PVK 943
    Length:943
    Mass (Da):103,151
    Last modified:September 2, 2008 - v1
    Checksum:i01B5958EAC6C5C54
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM177140 Genomic DNA. Translation: CAQ66866.1.
    RefSeqiYP_001987724.1. NC_010999.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ66866; CAQ66866; LCABL_17860.
    GeneIDi6406655.
    KEGGilcb:LCABL_17860.
    PATRICi22213015. VBILacCas89204_1693.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM177140 Genomic DNA. Translation: CAQ66866.1 .
    RefSeqi YP_001987724.1. NC_010999.1.

    3D structure databases

    ProteinModelPortali B3WER5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 543734.LCABL_17860.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ66866 ; CAQ66866 ; LCABL_17860 .
    GeneIDi 6406655.
    KEGGi lcb:LCABL_17860.
    PATRICi 22213015. VBILacCas89204_1693.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi RSANNAN.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci LCAS543734:GCHL-1763-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Lactobacillus casei BL23 complete genome sequence."
      Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BL23.

    Entry informationi

    Entry nameiIF2_LACCB
    AccessioniPrimary (citable) accession number: B3WER5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3