Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-dependent helicase/deoxyribonuclease subunit B

Gene

rexB

Organism
Lactobacillus casei (strain BL23)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCAS543734:GCHL-1689-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase/deoxyribonuclease subunit BUniRule annotation (EC:3.1.-.-UniRule annotation, EC:3.6.4.12UniRule annotation)
Alternative name(s):
ATP-dependent helicase/nuclease RexBUniRule annotation
Gene namesi
Name:rexBUniRule annotation
Ordered Locus Names:LCABL_17120
OrganismiLactobacillus casei (strain BL23)
Taxonomic identifieri543734 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11791179ATP-dependent helicase/deoxyribonuclease subunit BPRO_0000379368Add
BLAST

Interactioni

Subunit structurei

Heterodimer of AddA and RexB.UniRule annotation

Protein-protein interaction databases

STRINGi543734.LCABL_17120.

Family & Domainsi

Sequence similaritiesi

Belongs to the helicase family. AddB/RexB type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C5N. Bacteria.
COG3857. LUCA.
HOGENOMiHOG000033806.
KOiK16899.
OMAiDYKSSAK.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01453. AddB_type2. 1 hit.
InterProiIPR014141. DNA_helicase_suRexB.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

B3WEJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLQFILGDA TTDHAGTMAT MVQANLQADS QNQIFYLVPN HIKFEAEVDL
60 70 80 90 100
LKRLRAQAAS VNGVYAQNRV QVLSFSRLAW YFLKNTALYQ QPRLDRASNT
110 120 130 140 150
MLVAKILGES KEELTIYAGE AHNTGFVTQL ADQLSELVTG RITAEDLNTT
160 170 180 190 200
VAALTPGDRH RAKLRDLGII LDHYEAEIGP YATNASLLSG LQQVMRNQDL
210 220 230 240 250
SHTFIYLNDF NVFSASETGL VETMIETAAE VTVSLVLNKP YPAAPPVAPN
260 270 280 290 300
LFLPAGRLYH RLYQKAKTMK VPIRLDRFAK PRPLSEGMNH LADWWQTSTN
310 320 330 340 350
LQPQAPAQTA QNKEVELAVA TDPYHELRTV ARQIYQAVRQ GARYRDFLIL
360 370 380 390 400
ARRLDPYAAV IPAIFEEFNI PQFTDLERPM KDHPLVVLIE SLFAIQDHDY
410 420 430 440 450
QYQDVMRLLH TELLLPENMD IAAFRDALDT TDNHLVRTGI TGKKRWTQTD
460 470 480 490 500
PWRYFQRNPN ADDSQLDPEA DKTAQINAIK TLVADTVPQL LRQWQTAKTG
510 520 530 540 550
REAAASLYQW LQTTGVIDQL NVWRQTANAD GDLSRSQANE QAWDTFTQLL
560 570 580 590 600
NDYATILGEA DFNRDQFREL LAAGFASATY TQIPSTLDSV VISETGLVRL
610 620 630 640 650
AKAKHVYVIG ATNTAMPDVP NDSGVLNSEE RQLLAAQLPD DRFLPEQGPT
660 670 680 690 700
TTLGDPFINY LGFMAASEKL TLSYPMQNTQ ENSENQASPY FRQLAQALQL
710 720 730 740 750
TPATWAPAGL GTSLKAVLGS PRAMLSDFVR AAGEAQHQKL PLSRSWQGVL
760 770 780 790 800
ASLKQTKLAP LAQKLAGSLT YQNNPGRLDP TLAVQLYGRD MNVSVSRLET
810 820 830 840 850
YYRNQFEYFL KYGLLLQPRP EFELSPADTG SLFHAVLDQY LTQLRDAGQT
860 870 880 890 900
LADVTAADVA AAVPPLVAAI TKRPGYEILG STHRMAYLTS RLSRLLIQVL
910 920 930 940 950
TNMRQQQRRT GFRPMRTELQ FGQIGDTRGL PGLSWPLPHG GRVNVRGKID
960 970 980 990 1000
RLDVYRESDA QRFMVVDYKS TQHRFDDSDA YYGIALQMLT YVEAMANVPA
1010 1020 1030 1040 1050
DPPFVPAGAL YFHLQDPKFK FSTDLDLDID RLKAFKYLGF LVAKDGADLA
1060 1070 1080 1090 1100
AVDKTISAET GGRSMMVPLG FKKDGAFNYN QSNILTPEDL SAYLLHNQAL
1110 1120 1130 1140 1150
IIDAASRILA GDIALAPFQY GQESTVISNS DYQSIMLFDP ATGFDHYNHV
1160 1170
PKLKRKEVLG RVTTDPTQIP HHRQEDSQA
Length:1,179
Mass (Da):131,712
Last modified:September 2, 2008 - v1
Checksum:iB3AC181C32F5DB14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM177140 Genomic DNA. Translation: CAQ66793.1.
RefSeqiWP_012491617.1. NC_010999.1.

Genome annotation databases

EnsemblBacteriaiCAQ66793; CAQ66793; LCABL_17120.
KEGGilcb:LCABL_17120.
PATRICi22212865. VBILacCas89204_1619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM177140 Genomic DNA. Translation: CAQ66793.1.
RefSeqiWP_012491617.1. NC_010999.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi543734.LCABL_17120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ66793; CAQ66793; LCABL_17120.
KEGGilcb:LCABL_17120.
PATRICi22212865. VBILacCas89204_1619.

Phylogenomic databases

eggNOGiENOG4105C5N. Bacteria.
COG3857. LUCA.
HOGENOMiHOG000033806.
KOiK16899.
OMAiDYKSSAK.

Enzyme and pathway databases

BioCyciLCAS543734:GCHL-1689-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01453. AddB_type2. 1 hit.
InterProiIPR014141. DNA_helicase_suRexB.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADDB_LACCB
AccessioniPrimary (citable) accession number: B3WEJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.