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B3WEG3

- FTHS_LACCB

UniProt

B3WEG3 - FTHS_LACCB

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus casei (strain BL23)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCAS543734:GCHL-1660-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:LCABL_16830
OrganismiLactobacillus casei (strain BL23)
Taxonomic identifieri543734 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001206: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_1000196810Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi543734.LCABL_16830.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3WEG3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDIEIAQAN EATAMWPITK VAAGLGLSED DLELYGKAKA KLSFSALNAL
60 70 80 90 100
KDKPFGKLVL VTSINPTPAG EGKSTITVGL GDALQQRGKH PVIALREPSL
110 120 130 140 150
GPVMGMKGGA TGGGYAQVVP MEDINLHFTG DMHALTTAVD TLAALIDNHL
160 170 180 190 200
QQGNTLNIDP RRILWKRALD INDRALRHVT IGLGGPTSGV PREDGFDITV
210 220 230 240 250
ASELMAVLCL AENIADLKAR IGRIVIGYTY DRQPVTVADL KVTGAIAMLL
260 270 280 290 300
RDALKPNLVQ TLEHTPAFIH GGPFANIAHG CNSVLATRTA LQLGDIAITE
310 320 330 340 350
AGFGADLGGE KFMDIKTPVL GKTPDAVVIV ATVRALKYNG GVALKDLQTE
360 370 380 390 400
NVEALAQGFG NLKRHIHSMQ SYGVPVVVAI NRFTSDTDAE IQFLIDACAK
410 420 430 440 450
LNVKAVTATV WADGGRGGLA VADAVLAALD QPAHFTRLYD PQSDVKTKIK
460 470 480 490 500
TIVQKIYGGA DVDYEGKANS ALRTIVKNGW QDLPVCMAKT QYSLTDNAKT
510 520 530 540 550
LGAPEGFTIH VRDIIPKLGA GFLVVMTGSV LTMPGLPKVP AALNMDVTDD

GKISGLF
Length:557
Mass (Da):58,901
Last modified:September 2, 2008 - v1
Checksum:i70A7DE2024BAA25B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM177140 Genomic DNA. Translation: CAQ66764.1.
RefSeqiYP_001987622.1. NC_010999.1.

Genome annotation databases

EnsemblBacteriaiCAQ66764; CAQ66764; LCABL_16830.
GeneIDi6406161.
KEGGilcb:LCABL_16830.
PATRICi22212805. VBILacCas89204_1589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM177140 Genomic DNA. Translation: CAQ66764.1 .
RefSeqi YP_001987622.1. NC_010999.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 543734.LCABL_16830.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ66764 ; CAQ66764 ; LCABL_16830 .
GeneIDi 6406161.
KEGGi lcb:LCABL_16830.
PATRICi 22212805. VBILacCas89204_1589.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LCAS543734:GCHL-1660-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Lactobacillus casei BL23 complete genome sequence."
    Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BL23.

Entry informationi

Entry nameiFTHS_LACCB
AccessioniPrimary (citable) accession number: B3WEG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: October 1, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3