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B3WEG3

- FTHS_LACCB

UniProt

B3WEG3 - FTHS_LACCB

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, LCABL_16830
Organism
Lactobacillus casei (strain BL23)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCAS543734:GCHL-1660-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:LCABL_16830
OrganismiLactobacillus casei (strain BL23)
Taxonomic identifieri543734 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001206: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000196810Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi543734.LCABL_16830.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3WEG3-1 [UniParc]FASTAAdd to Basket

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MSDIEIAQAN EATAMWPITK VAAGLGLSED DLELYGKAKA KLSFSALNAL    50
KDKPFGKLVL VTSINPTPAG EGKSTITVGL GDALQQRGKH PVIALREPSL 100
GPVMGMKGGA TGGGYAQVVP MEDINLHFTG DMHALTTAVD TLAALIDNHL 150
QQGNTLNIDP RRILWKRALD INDRALRHVT IGLGGPTSGV PREDGFDITV 200
ASELMAVLCL AENIADLKAR IGRIVIGYTY DRQPVTVADL KVTGAIAMLL 250
RDALKPNLVQ TLEHTPAFIH GGPFANIAHG CNSVLATRTA LQLGDIAITE 300
AGFGADLGGE KFMDIKTPVL GKTPDAVVIV ATVRALKYNG GVALKDLQTE 350
NVEALAQGFG NLKRHIHSMQ SYGVPVVVAI NRFTSDTDAE IQFLIDACAK 400
LNVKAVTATV WADGGRGGLA VADAVLAALD QPAHFTRLYD PQSDVKTKIK 450
TIVQKIYGGA DVDYEGKANS ALRTIVKNGW QDLPVCMAKT QYSLTDNAKT 500
LGAPEGFTIH VRDIIPKLGA GFLVVMTGSV LTMPGLPKVP AALNMDVTDD 550
GKISGLF 557
Length:557
Mass (Da):58,901
Last modified:September 2, 2008 - v1
Checksum:i70A7DE2024BAA25B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM177140 Genomic DNA. Translation: CAQ66764.1.
RefSeqiYP_001987622.1. NC_010999.1.

Genome annotation databases

EnsemblBacteriaiCAQ66764; CAQ66764; LCABL_16830.
GeneIDi6406161.
KEGGilcb:LCABL_16830.
PATRICi22212805. VBILacCas89204_1589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM177140 Genomic DNA. Translation: CAQ66764.1 .
RefSeqi YP_001987622.1. NC_010999.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 543734.LCABL_16830.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ66764 ; CAQ66764 ; LCABL_16830 .
GeneIDi 6406161.
KEGGi lcb:LCABL_16830.
PATRICi 22212805. VBILacCas89204_1589.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LCAS543734:GCHL-1660-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Lactobacillus casei BL23 complete genome sequence."
    Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BL23.

Entry informationi

Entry nameiFTHS_LACCB
AccessioniPrimary (citable) accession number: B3WEG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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