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Protein

UvrABC system protein C

Gene

uvrC

Organism
Lactobacillus casei (strain BL23)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein C
Short name:
Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene namesi
Name:uvrC
Ordered Locus Names:LCABL_15670
OrganismiLactobacillus casei (strain BL23)
Taxonomic identifieri543734 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000994951 – 602UvrABC system protein CAdd BLAST602

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.

Structurei

3D structure databases

SMRiB3WE47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 92GIY-YIGAdd BLAST78
Domaini197 – 232UVRAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279960.
KOiK03703.
OMAiLFPIRQC.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiView protein in InterPro
IPR000305. GIY-YIG_endonuc.
IPR035901. GIY-YIG_endonuc_sf.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
PfamiView protein in Pfam
PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
SMARTiView protein in SMART
SM00465. GIYc. 1 hit.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiView protein in PROSITE
PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.

Sequencei

Sequence statusi: Complete.

B3WE47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAHIEHKL SLLPDLPGSY QMKDINGKII YVGKAKNLKN RVRSYFKSSH
60 70 80 90 100
DGKVAAMVSQ VADFDFIVTS TDKEAFLLEI TLIQKYQPYY NIKLKKGTGY
110 120 130 140 150
PYIKITHERD PKIEITGTIR KDGGYYFGPY PNVYAAQETM HFIQKVYPLR
160 170 180 190 200
RCNGYQGRPC LYYHMGQCLG ACFRTVPEKE YTDQIERIKR FLNGNVGKAK
210 220 230 240 250
ASLTAKMERA AKNLQFERAA EIRDQLHYIE QTVEKQKIIS HDNTTRDLFN
260 270 280 290 300
FYMDKGWISI QVFFIRQARL MKRESRLFPV VNTAKEEFES FILQFYSRKN
310 320 330 340 350
NVKPREVLVP AALDNKVLAD ILEIPVRTPQ RGEKRDLMAL AAKNSQIKLE
360 370 380 390 400
DKFRLMELDN RTTIGAMKEL MAALNLPMGH VAEAFDHSHI QGADPVSAMV
410 420 430 440 450
QFVDGQPAKN NYRKYKLDAD KTHNGADEAA NTREVIRRRY TRLLKERAPL
460 470 480 490 500
PDLILMDGGE IEMNAAKDVL ENELNLDIPV AGMVKNNKHK TAALLFGNAD
510 520 530 540 550
QLINLDPKSQ GFYLLERIQD EVHRFAITFH RQLHAKNSLA SRLEGIKGVG
560 570 580 590 600
PKTRLKLLRK FKTINKIKEA PLEDIQELGI SKKVAQALKL SLTAEPTPAR

RV
Length:602
Mass (Da):68,874
Last modified:September 2, 2008 - v1
Checksum:i73F3BF1D7BCDD19D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM177140 Genomic DNA. Translation: CAQ66648.1.
RefSeqiWP_012491562.1. NC_010999.1.

Genome annotation databases

EnsemblBacteriaiCAQ66648; CAQ66648; LCABL_15670.
KEGGilcb:LCABL_15670.

Similar proteinsi

Entry informationi

Entry nameiUVRC_LACCB
AccessioniPrimary (citable) accession number: B3WE47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: October 25, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families