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Protein

Xanthine phosphoribosyltransferase

Gene

xpt

Organism
Lactobacillus casei (strain BL23)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (xpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei27 – 271XanthineUniRule annotation
Binding sitei156 – 1561XanthineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciLCAS543734:GCHL-1257-MONOMER.
UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Short name:
XPRTaseUniRule annotation
Gene namesi
Name:xptUniRule annotation
Ordered Locus Names:LCABL_12770
OrganismiLactobacillus casei (strain BL23)
Taxonomic identifieri543734 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Xanthine phosphoribosyltransferasePRO_1000138238Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi543734.LCABL_12770.

Structurei

3D structure databases

ProteinModelPortaliB3WDB0.
SMRiB3WDB0. Positions 1-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 13255-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UPS. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000036777.
KOiK03816.
OMAiHQIDPEL.
OrthoDBiEOG6GTZNX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

B3WDB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLEDRIKK DGQVIGTDVL KVDNFLNHQV DPDLMADLGH EFYRRFSNEP
60 70 80 90 100
ITKILTVESS GIAPAIATAM EFHKPLVFAR KHKSLTLKDH LYTATVYSFT
110 120 130 140 150
KKTSNEIAIS RKFLSADDNV LIIDDFLANG QAVEGLMDII AQAGATLSGV
160 170 180 190
GIVIEKTFQK GRKLLDEKHV RVESLARINA FENGQVIFAP ED
Length:192
Mass (Da):21,385
Last modified:September 2, 2008 - v1
Checksum:i831BF957156756B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM177140 Genomic DNA. Translation: CAQ66361.1.
RefSeqiWP_003566514.1. NC_010999.1.

Genome annotation databases

EnsemblBacteriaiCAQ66361; CAQ66361; LCABL_12770.
KEGGilcb:LCABL_12770.
PATRICi22212019. VBILacCas89204_1199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM177140 Genomic DNA. Translation: CAQ66361.1.
RefSeqiWP_003566514.1. NC_010999.1.

3D structure databases

ProteinModelPortaliB3WDB0.
SMRiB3WDB0. Positions 1-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi543734.LCABL_12770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ66361; CAQ66361; LCABL_12770.
KEGGilcb:LCABL_12770.
PATRICi22212019. VBILacCas89204_1199.

Phylogenomic databases

eggNOGiENOG4108UPS. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000036777.
KOiK03816.
OMAiHQIDPEL.
OrthoDBiEOG6GTZNX.

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658.
BioCyciLCAS543734:GCHL-1257-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Lactobacillus casei BL23 complete genome sequence."
    Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BL23.

Entry informationi

Entry nameiXPT_LACCB
AccessioniPrimary (citable) accession number: B3WDB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: December 9, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.