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B3WCK9 (GUAC_LACCB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP reductase
EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:LCABL_10240
OrganismLactobacillus casei (strain BL23) [Complete proteome] [HAMAP]
Taxonomic identifier543734 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329GMP reductase HAMAP MF_01511
PRO_1000146138

Regions

Nucleotide binding207 – 23024NADP Potential

Sites

Active site1781Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
B3WCK9 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 150A3068E816152E

FASTA32936,504
        10         20         30         40         50         60 
MNNGMQIFDY EDIQMIPNKC VVQSRKEVDT SVKFGPHTFK IPVVPANMQT IIDEPLAIWL 

        70         80         90        100        110        120 
AEHDYFYIMH RFQPERRMDF VRDMKKRGLI ASISVGVKDD EFDFIEALAA NELTPDYITI 

       130        140        150        160        170        180 
DIAHGYAQVV IDMIQHIKHY LPNAFVIAGN VGTPEAVREL ENAGADATKV GIGPGKVCLT 

       190        200        210        220        230        240 
KLKTGFGTGG WQLAAVRWCA KAARKPIIAD GGIRNNGDIA KSIRFGATMC MIGSLFAGHE 

       250        260        270        280        290        300 
ETPGKHVNID GKEYQEYYGS ASEYQKGTHH NVEGKKILLP VKGKIGDTLK EMQEDLQSAV 

       310        320 
SYAGGRDLES LTKVDYVIVK NSIFNGDQY

« Hide

References

[1]"Lactobacillus casei BL23 complete genome sequence."
Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BL23.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM177140 Genomic DNA. Translation: CAQ66110.1.
RefSeqYP_001986968.1. NC_010999.1.

3D structure databases

ProteinModelPortalB3WCK9.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3WCK9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6406784.
GenomeReviewsGene locus LCABL_10240 in contig FM177140_GR.
KEGGlcb:LCABL_10240.
PATRIC22211507. VBILacCas89204_0946.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG298985.
OMAPDYITID.
ProtClustDBPRK05458.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00364.
PANTHERPTHR11911:SF30. PTHR11911:SF30. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_LACCB
AccessionPrimary (citable) accession number: B3WCK9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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