B3WCK5 (UPPP_LACCB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	LCABL_10200

Organism

Lactobacillus casei (strain BL23) [Complete proteome] [HAMAP]

Taxonomic identifier

543734 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus casei group › Lactobacillus casei

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000197377
Regions
	Transmembrane	2 – 22	21	Helical; Potential
	Transmembrane	43 – 63	21	Helical; Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Transmembrane	110 – 130	21	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Transmembrane	252 – 272	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B3WCK5 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: CEB5E09DD91BEAF0	FASTA	272	30,045
	10 20 30 40 50 60 MFDIIKAVII GIVEGLTEFL PISSTGHIDL VNHVIKLSQS QDFISMFEYV IQFGAILAVV 70 80 90 100 110 120 LLYFNKLNPF SKPTAKARNA TWQLWAKVII AVLPSAVVGL PLNSWMDEHL HTPIVVATTL 130 140 150 160 170 180 IVYGILFIIL ENYLKNKSAH ITTLADITYQ TALLIGLFQV LSIVPGTSRS GATILGALLI 190 200 210 220 230 240 GTSRYVATEF SFFLAIPTMV GVLIIKIGKY LWQGNGFSGE QWAVLMTGSI VSFLVAIVAI 250 260 270 KWLLKFVQTH DFKPFGWYRI ALGAIVLLVM FI

References

[1]	"Lactobacillus casei BL23 complete genome sequence." Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BL23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM177140 Genomic DNA. Translation: CAQ66106.1.
RefSeq	YP_001986964.1. NC_010999.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	543734.LCABL_10200.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAQ66106; CAQ66106; LCABL_10200.
GeneID	6405694.
KEGG	lcb:LCABL_10200.
PATRIC	22211499. VBILacCas89204_0942.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	NDWLDKH.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_LACCB

Accession

Primary (citable) accession number: B3WCK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 2, 2008
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program