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B3WCK5 (UPPP_LACCB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:LCABL_10200
OrganismLactobacillus casei (strain BL23) [Complete proteome] [HAMAP]
Taxonomic identifier543734 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197377

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane252 – 27221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B3WCK5 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: CEB5E09DD91BEAF0

FASTA27230,045
        10         20         30         40         50         60 
MFDIIKAVII GIVEGLTEFL PISSTGHIDL VNHVIKLSQS QDFISMFEYV IQFGAILAVV 

        70         80         90        100        110        120 
LLYFNKLNPF SKPTAKARNA TWQLWAKVII AVLPSAVVGL PLNSWMDEHL HTPIVVATTL 

       130        140        150        160        170        180 
IVYGILFIIL ENYLKNKSAH ITTLADITYQ TALLIGLFQV LSIVPGTSRS GATILGALLI 

       190        200        210        220        230        240 
GTSRYVATEF SFFLAIPTMV GVLIIKIGKY LWQGNGFSGE QWAVLMTGSI VSFLVAIVAI 

       250        260        270 
KWLLKFVQTH DFKPFGWYRI ALGAIVLLVM FI 

« Hide

References

[1]"Lactobacillus casei BL23 complete genome sequence."
Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BL23.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM177140 Genomic DNA. Translation: CAQ66106.1.
RefSeqYP_001986964.1. NC_010999.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING543734.LCABL_10200.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAQ66106; CAQ66106; LCABL_10200.
GeneID6405694.
KEGGlcb:LCABL_10200.
PATRIC22211499. VBILacCas89204_0942.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycLCAS543734:GCHL-1001-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_LACCB
AccessionPrimary (citable) accession number: B3WCK5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families