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B3WCD5

- SYL_LACCB

UniProt

B3WCD5 - SYL_LACCB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus casei (strain BL23)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei578 – 5781ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLCAS543734:GCHL-930-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:LCABL_09490
    OrganismiLactobacillus casei (strain BL23)
    Taxonomic identifieri543734 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001206: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 803803Leucine--tRNA ligasePRO_1000091325Add
    BLAST

    Proteomic databases

    PRIDEiB3WCD5.

    Interactioni

    Protein-protein interaction databases

    STRINGi543734.LCABL_09490.

    Structurei

    3D structure databases

    ProteinModelPortaliB3WCD5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi575 – 5795"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3WCD5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYDHHEIDK KWQRYWAEHN EFNTTTDPKK PNYYALDMFP YPSGQGLHVG    50
    HPEGYTATDI VARMKRMQGF NVLHPMGWDA FGLPAEQYAL NTGHNPKTFT 100
    KQNIETFKRQ INSLGFSYDW NREINTTDPN YYKWTQWIFE QLYKHGLAYE 150
    AEVPVNWSPD LGTVVANEEV IDGKTERGGF PVVRKPMRQW MLKITAYAEK 200
    LLTDLDDLDW PESIKQMQRN WIGKSTGAQI TFRVTDSHEP FDVFTTRPDT 250
    LFGATYVVMA PEHELVQKIT TPAQQAVVDA YIDEAAHKSD LDRTALDKEK 300
    TGVWTGAYAT NPVNGEKLPI WISDYVLASY GTGAIMSVPA HDDRDYAFAK 350
    KFGIEIKPVI EGGNVDEAAY TGDGVHINSG FLDGLNEHDA IDRMIKWLED 400
    KGIGSAKINY KLRDWVFSRQ RYWGEPIPVI HWEDGETTLV PEDELPLTLP 450
    EEADIKPSGT GESPLANLTD WVNVVDKNGR KGKRETNTMP QWAGSSWYFL 500
    RFVDPHNKEA LADYDKLKAW MPVDLYIGGA EHAVLHLLYA RFWNLFLYDI 550
    GAIPNKEPFQ RLFNQGMILG DNHEKMSKSK GNVVNPDDVV DEYGADTLRL 600
    YEMFMGPLDA GIAWSTKGLA GARKFLDRVW SAFIDDEGKL RDRITTINDG 650
    RLDKVYNETV KKVTEDYDAL HFNTAISQMM VFINSARKDD DLPLEYVEGF 700
    VKMLAPIAPH LMEEIWSRLG HDHSLTYAPW PSYDESKIKT DTYDMMIQVN 750
    GKLRGSITAD VNESDDEIKQ AALANDNVQK FTAGKDIKKI IVVPRKIVNI 800
    VAK 803
    Length:803
    Mass (Da):91,527
    Last modified:September 2, 2008 - v1
    Checksum:i487E45B7E7F7BA4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM177140 Genomic DNA. Translation: CAQ66036.1.
    RefSeqiYP_001986894.1. NC_010999.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ66036; CAQ66036; LCABL_09490.
    GeneIDi6404658.
    KEGGilcb:LCABL_09490.
    PATRICi22211365. VBILacCas89204_0876.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM177140 Genomic DNA. Translation: CAQ66036.1 .
    RefSeqi YP_001986894.1. NC_010999.1.

    3D structure databases

    ProteinModelPortali B3WCD5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 543734.LCABL_09490.

    Proteomic databases

    PRIDEi B3WCD5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ66036 ; CAQ66036 ; LCABL_09490 .
    GeneIDi 6404658.
    KEGGi lcb:LCABL_09490.
    PATRICi 22211365. VBILacCas89204_0876.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LCAS543734:GCHL-930-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Lactobacillus casei BL23 complete genome sequence."
      Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BL23.

    Entry informationi

    Entry nameiSYL_LACCB
    AccessioniPrimary (citable) accession number: B3WCD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3