B3WBT3 (MTLD_LACCB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	LCABL_31030

Organism

Lactobacillus casei (strain BL23) [Complete proteome] [HAMAP]

Taxonomic identifier

543734 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 383	383	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000124390
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3WBT3 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 511A2081DFAFE6C3	FASTA	383	42,453
	10 20 30 40 50 60 MEAVHFGAGN IGRGFIGETL AANGFKINFV DVNETIINAL NQRGEYTITL AAPGEKKIHV 70 80 90 100 110 120 DNVDGLNNAK DPEAVVKAIA QADLVTTAIG PKILPIIAPL IAQGLQARDA ANNHQALDVI 130 140 150 160 170 180 ACENMIGGSQ SLKKSVYEHL DDAGKTFADT YVGFPNAAVD RIVPQQKHDD PLAVSVEDFK 190 200 210 220 230 240 EWVVDESQMK NKDLKLKTVD YVPDLEPYIE RKLFSVNTGH ATTAYTGKYL GYTTIGDAIK 250 260 270 280 290 300 DPKVFNQAKG ALAETRSLLL SEFKNFDEKD LENYQNRVLQ RFQNPYISDD ISRVARTPIR 310 320 330 340 350 360 KLGYDERFIR PIRELKERGL NYSVLMDTVG MMFHYVEPND AEAVKLQAML KDQPLVDVIK 370 380 EVTGLKDAGL IDEVEASVKS KDR

References

[1]	"Lactobacillus casei BL23 complete genome sequence." Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BL23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM177140 Genomic DNA. Translation: CAQ68152.1.
RefSeq	YP_001989010.1. NC_010999.1.
3D structure databases
ProteinModelPortal	B3WBT3.
ModBase	Search...
Protein-protein interaction databases
STRING	B3WBT3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6406141.
GenomeReviews	Gene locus LCABL_31030 in contig FM177140_GR.
KEGG	lcb:LCABL_31030.
PATRIC	22215622. VBILacCas89204_2967.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG568825.
OMA	FANTAVD.
ProtClustDB	PRK02318.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR023027. Mannitol_DH_CS. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00009.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_LACCB

Accession

Primary (citable) accession number: B3WBT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	September 2, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program