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B3WAR0 (ALR_LACCB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:LCABL_27280
OrganismLactobacillus casei (strain BL23) [Complete proteome] [HAMAP]
Taxonomic identifier543734 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Alanine racemase HAMAP-Rule MF_01201
PRO_1000138605

Sites

Active site401Proton acceptor; specific for D-alanine By similarity
Active site2701Proton acceptor; specific for L-alanine By similarity
Binding site1401Substrate By similarity
Binding site3171Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue401N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B3WAR0 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: C4AFDC87E931332F

FASTA37841,299
        10         20         30         40         50         60 
MTIGNFRPAT VLIDETAILH NIQHEVARLK KQTQLFAVVK ADAYGHGMLR VARVAKAAGA 

        70         80         90        100        110        120 
TGFCVAILDE ALGLRKADYS EPVLVLGIVP SQYAAIAAAQ TISLPVSSTE WLEQALPVLE 

       130        140        150        160        170        180 
AQPELPPLRI HLALDTGMGR IGFTEDQALK TAVAFVEAHP KQFVIEGVFT HFATADAPDD 

       190        200        210        220        230        240 
TYFKQQVNKF NHLVNLLPSR PRYVHVSNSA TSLWHAACNG NMIRYGVAIY GLNPSGDAIP 

       250        260        270        280        290        300 
TTPFPLEPAL SLESELTYCK QVHAGDGISY GVTYRAKGDE FIGTVPIGYA DGWLRRLQGF 

       310        320        330        340        350        360 
HVLVDGQYCE IVGRICMDQF MIRLPKAYPA GTKVVLVGQS GDQEITLLDV AKYSKTIHYE 

       370 
IACNLTPRLK RQSVNPVD 

« Hide

References

[1]"Lactobacillus casei BL23 complete genome sequence."
Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BL23.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM177140 Genomic DNA. Translation: CAQ67779.1.
RefSeqYP_001988637.1. NC_010999.1.

3D structure databases

ProteinModelPortalB3WAR0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING543734.LCABL_27280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAQ67779; CAQ67779; LCABL_27280.
GeneID6405304.
KEGGlcb:LCABL_27280.
PATRIC22214872. VBILacCas89204_2595.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031444.
KOK01775.
OMAELMAVQH.
OrthoDBEOG6PP9NJ.
ProtClustDBCLSK842788.

Enzyme and pathway databases

BioCycLCAS543734:GCHL-2693-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_LACCB
AccessionPrimary (citable) accession number: B3WAR0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways