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B3W9T6 (ADD_LACCB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:add
Ordered Locus Names:LCABL_23880
OrganismLactobacillus casei (strain BL23) [Complete proteome] [HAMAP]
Taxonomic identifier543734 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenosine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Adenosine deaminase HAMAP MF_00540
PRO_1000128850

Sites

Active site2021Proton donor By similarity
Metal binding151Zinc; catalytic By similarity
Metal binding171Zinc; catalytic By similarity
Metal binding1991Zinc; catalytic By similarity
Metal binding2791Zinc; catalytic By similarity
Binding site171Substrate By similarity
Binding site191Substrate By similarity
Binding site1721Substrate; via amide nitrogen and carbonyl oxygen By similarity
Site2221Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
B3W9T6 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: AF9265842B0CE806

FASTA33937,031
        10         20         30         40         50         60 
MDFQTLHQLS KTELHCHLDG SLSLSCIRQL AKMIDRKLPA TDDELRRLVQ APADSENLGD 

        70         80         90        100        110        120 
YLKAFDFVAP LLQTKKALQL AAYDVVEQAA EENVRYIEIR FAPVFSLAGG LSLVEATQAV 

       130        140        150        160        170        180 
IEGLHQGMAT YDIMAKALVC GMRQLPNTDN QTMFKTTAPL LGSTLVGGDF AGNEADFPTN 

       190        200        210        220        230        240 
VCAPAIKTAQ SLGVPLTFHA GECHCPQNIA EAVRLGIPRI GHATACFDQP ALIEKIVETG 

       250        260        270        280        290        300 
TTVELCLTSN LQTKAARTLA EFPYQALKKA GAKITINTDN RTVSNTTLTQ EYQRYQQAFG 

       310        320        330 
TTAVDFLAFN LNAIDAAFIP DADKKSLRDR LHQDYATYC

« Hide

References

[1]"Lactobacillus casei BL23 complete genome sequence."
Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BL23.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM177140 Genomic DNA. Translation: CAQ67455.1.
RefSeqYP_001988313.1. NC_010999.1.

3D structure databases

ProteinModelPortalB3W9T6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3W9T6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6406440.
GenomeReviewsGene locus LCABL_23880 in contig FM177140_GR.
KEGGlcb:LCABL_23880.
PATRIC22214204. VBILacCas89204_2275.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG630382.
OMAPYYMAMN.
ProtClustDBCLSK2318309.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADD_LACCB
AccessionPrimary (citable) accession number: B3W9T6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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