Reviewed, UniProtKB/Swiss-Prot B3W9T6 (ADD_LACCB)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	LCABL_23880

Organism

Lactobacillus casei (strain BL23) [Complete proteome] [HAMAP]

Taxonomic identifier

543734 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Adenosine deaminase HAMAP MF_00540		PRO_1000128850
Sites
	Active site	199	1	Potential
	Active site	246	1	Potential
	Active site	279	1	Potential
	Active site	280	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	B3W9T6-1 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: AF9265842B0CE806	FASTA	339	37,031
	10 20 30 40 50 60 MDFQTLHQLS KTELHCHLDG SLSLSCIRQL AKMIDRKLPA TDDELRRLVQ APADSENLGD 70 80 90 100 110 120 YLKAFDFVAP LLQTKKALQL AAYDVVEQAA EENVRYIEIR FAPVFSLAGG LSLVEATQAV 130 140 150 160 170 180 IEGLHQGMAT YDIMAKALVC GMRQLPNTDN QTMFKTTAPL LGSTLVGGDF AGNEADFPTN 190 200 210 220 230 240 VCAPAIKTAQ SLGVPLTFHA GECHCPQNIA EAVRLGIPRI GHATACFDQP ALIEKIVETG 250 260 270 280 290 300 TTVELCLTSN LQTKAARTLA EFPYQALKKA GAKITINTDN RTVSNTTLTQ EYQRYQQAFG 310 320 330 TTAVDFLAFN LNAIDAAFIP DADKKSLRDR LHQDYATYC

References

[1]	"Lactobacillus casei BL23 complete genome sequence." Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	FM177140 Genomic DNA. Translation: CAQ67455.1.
RefSeq	YP_001988313.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6406440.
GenomeReviews	Gene locus LCABL_23880 in contig FM177140_GR.
KEGG	lcb:LCABL_23880.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FLKKLDW.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_LACCB

Accession

Primary (citable) accession number: B3W9T6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 2, 2008
Last modified:	November 3, 2009
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)