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B3W963 (HEMH_LACCB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:LCABL_21650
OrganismLactobacillus casei (strain BL23) [Complete proteome] [HAMAP]
Taxonomic identifier543734 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Ferrochelatase HAMAP MF_00323
PRO_1000116055

Sites

Metal binding1851Iron By similarity
Metal binding2671Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B3W963 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 81CD7AE035467743

FASTA32136,273
        10         20         30         40         50         60 
MAKGLLIVNL GSPVSPETKD VRRYLREFLS DQNVITMPKA LWQPILRGFI LPFRSWRSAT 

        70         80         90        100        110        120 
FYKHEWTQAG SPLIAYTQVT RDRLRERLPD WDVQMAMNYG GEYPIGETLQ TMAARGDAPI 

       130        140        150        160        170        180 
VVIPLFPEYT QSTTKTILDK VAASGVKTVV IDRFYDHSDY QKILAQQIDD AYEAGAYDTV 

       190        200        210        220        230        240 
ILSYHGIPTA MVRHGDPYQQ ECETTTAGVK QYLKKVPQTK VEMCYQSKFG PVPWLKPYLR 

       250        260        270        280        290        300 
NRLMELAALG KRNVLVATPS FVADCLETLE ENNVQNYQTF RANGGKNFAT VRPMNGCEPF 

       310        320 
CDFLAKLAKD KIAAEANHGK A

« Hide

References

[1]"Lactobacillus casei BL23 complete genome sequence."
Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A., Deutscher J.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BL23.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM177140 Genomic DNA. Translation: CAQ67232.1.
RefSeqYP_001988090.1. NC_010999.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB3W963.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6406228.
GenomeReviewsGene locus LCABL_21650 in contig FM177140_GR.
KEGGlcb:LCABL_21650.
PATRIC22213765. VBILacCas89204_2056.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMAIRPAKSA.
ProtClustDBCLSK821272.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_LACCB
AccessionPrimary (citable) accession number: B3W963
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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