B3W8L3 (B3W8L3_LACCB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP MF_01671
EC=1.1.1.18 HAMAP MF_01671
EC=1.1.1.n6 HAMAP MF_01671

Alternative name(s):
Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP MF_01671

Gene names

Name:	iolG1 EMBL CAQ65353.1
Synonyms:	iolG HAMAP MF_01671
Ordered Locus Names:	LCABL_02210

Organism

Lactobacillus casei (strain BL23) [Complete proteome] [HAMAP] EMBL CAQ65353.1

Taxonomic identifier

543734 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively By similarity. HAMAP MF_01671
Catalytic activity	D-chiro-inositol + NAD+ = 2,3,5/4,6-pentahydroxycyclohexanone + NADH. HAMAP MF_01671 Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671 SAAS SAAS000683
Pathway	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. SAAS SAAS000683 HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family. HAMAP MF_01671

Ontologies

Keywords
Ligand	NAD SAAS SAAS000683 HAMAP MF_01671
Molecular function	Oxidoreductase SAAS SAAS023794 HAMAP MF_01671
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3W8L3 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 1FCB85142F4C942A	FASTA	346	37,964
	10 20 30 40 50 60 MVVKVGVIGT GAMGRAHIDR LTNVLTGAEV VAVTDIDHEA AEAAVRDFHL NAKVYPDDTS 70 80 90 100 110 120 LLQDPDIDAV FVVSFGGAHE ATVLKALDTD KFIFTEKPLA TTLEGAKRIV DKELTKSKKV 130 140 150 160 170 180 IQVGFMRRYD QGIRALKEKL DTGIIGAPLV VRASHINPNV ASNYSNEMAI TDTLIHEIDE 190 200 210 220 230 240 MHWLLDDEYT SIQITYPRQS AEVRNEGLHD PQLATLTTKK GTVIQVLVHV TAQYGYEVKL 250 260 270 280 290 300 EVIGETGELQ LPNYGLGPIL RSNANQQTAV EMSWINRFIQ AYNTEVQEFI DQVAKSEPPV 310 320 330 340 GPSAWDGYIA AITAAAANRS QKDQETVLIN VAGTPTFYQN KNAIHA

References

[1]

"Complete genome sequence of the probiotic Lactobacillus casei strain BL23." Maze A., Boel G., Zuniga M., Bourand A., Loux V., Yebra M.J., Monedero V., Correia K., Jacques N., Beaufils S., Poncet S., Joyet P., Milohanic E., Casaragola S., Auffray Y., Perez-Martinez G., Gibrat J.F., Zagorec M. , Francke C., Hartke A., Deutscher J. J. Bacteriol. 192:2647-2648(2010) Cited for: NUCLEOTIDE SEQUENCE. Strain: BL23 EMBL CAQ65353.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM177140 Genomic DNA. Translation: CAQ65353.1.
RefSeq	YP_001986211.1. NC_010999.1.
3D structure databases
ProteinModelPortal	B3W8L3.
ModBase	Search...
Protein-protein interaction databases
STRING	B3W8L3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6406058.
GenomeReviews	Gene locus LCABL_02210 in contig FM177140_GR.
KEGG	lcb:LCABL_02210.
PATRIC	22209955. VBILacCas89204_0212.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG612336.
OMA	IDSARTW.
ProtClustDB	CLSK2544124.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B3W8L3_LACCB

Accession

Primary (citable) accession number: B3W8L3

Entry history

Integrated into UniProtKB/TrEMBL:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)