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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Lactobacillus casei (strain BL23)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi151 – 158ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:LCABL_00010
OrganismiLactobacillus casei (strain BL23)
Taxonomic identifieri543734 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001219901 – 449Chromosomal replication initiator protein DnaAAdd BLAST449

Structurei

3D structure databases

ProteinModelPortaliB3W6N4
SMRiB3W6N4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
HOGENOMiHOG000235658
KOiK02313
OMAiREFNPLF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

B3W6N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNLEELWAY LNDKFREELT PVGYSTWIQT AKPVKLTKDK LEIEVPASLH
60 70 80 90 100
KAYWEKNLVT KVVEGVYEFA QLEVDPVIMT KDELQPAPAT DQRPAVEEDD
110 120 130 140 150
QNLTFKAKTH LNPKYTFDRF VIGKGNQMAH AAALAVAEAP GTTYNPLFIY
160 170 180 190 200
GGVGLGKTHL MQAIGNLVLD NNPAANIKYV TSENFANDFI NSIQTKQQEQ
210 220 230 240 250
FRQEYRNVDL LLVDDIQFFG DKEATQEEFF HTFNTLYENM KQIVLTSDRL
260 270 280 290 300
PNEIPKLQER LVSRFNKGLS VDVTPPDLET RIAILRNKAD AEDLSIPDDT
310 320 330 340 350
LSYIAGQIES NVRDLEGALV RVQAFSTMKN EDITTSLAAD ALKALKLDDR
360 370 380 390 400
SGQLTIPQIL NAVAKYFQLT VQDLKGKKRV KQIVIPRQIA MYLAREMTDN
410 420 430 440
SLPKIGQEIG GKDHTTVIHA HEKIMASMTT DENLKAQVIE LRNILKNRG
Length:449
Mass (Da):50,691
Last modified:September 2, 2008 - v1
Checksum:i22733AFEBFE68A62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM177140 Genomic DNA Translation: CAQ65133.1
RefSeqiWP_012490751.1, NC_010999.1

Genome annotation databases

EnsemblBacteriaiCAQ65133; CAQ65133; LCABL_00010
KEGGilcb:LCABL_00010

Similar proteinsi

Entry informationi

Entry nameiDNAA_LACCB
AccessioniPrimary (citable) accession number: B3W6N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health