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B3VQP5

- B3VQP5_9ENTO

UniProt

B3VQP5 - B3VQP5_9ENTO

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Protein

Genome polyprotein

Gene
N/A
Organism
Human poliovirus 1
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

NTP + H2O = NDP + phosphate.SAAS annotation
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1981 – 19811ManganeseImported
Metal bindingi1982 – 19821Manganese; via carbonyl oxygenImported
Metal bindingi2018 – 20181Zinc 1; via tele nitrogenImported
Metal bindingi2020 – 20201Zinc 1; via pros nitrogenImported
Metal bindingi2020 – 20201Zinc 2; via tele nitrogenImported
Metal bindingi2029 – 20291Zinc 1Imported
Metal bindingi2029 – 20291Zinc 2Imported
Metal bindingi2076 – 20761ManganeseImported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cysteine-type endopeptidase activity Source: InterPro
  3. ion channel activity Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. RNA binding Source: UniProtKB-KW
  6. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  7. RNA helicase activity Source: InterPro
  8. structural molecule activity Source: InterPro

GO - Biological processi

  1. pore formation by virus in membrane of host cell Source: UniProtKB-KW
  2. protein oligomerization Source: UniProtKB-KW
  3. RNA-protein covalent cross-linking Source: InterPro
  4. transcription, DNA-templated Source: InterPro
  5. viral entry into host cell Source: UniProtKB-KW
  6. viral RNA genome replication Source: InterPro
  7. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase, Viral ion channelSAAS annotation

Keywords - Biological processi

Host-virus interaction, Ion transport, Transport, Viral attachment to host cellSAAS annotation, Viral RNA replicationSAAS annotation, Virus entry into host cell

Keywords - Ligandi

ATP-binding, ManganeseImported, Metal-bindingImported, Nucleotide-binding, RNA-bindingSAAS annotation, ZincImported

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
OrganismiHuman poliovirus 1Imported
Taxonomic identifieri12080 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeEnterovirusEnterovirus C

Subcellular locationi

Host cytoplasm SAAS annotation
Host cytoplasmic vesicle membrane SAAS annotation; Peripheral membrane protein SAAS annotation; Cytoplasmic side SAAS annotation

GO - Cellular componenti

  1. host cell cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  2. integral to membrane of host cell Source: UniProtKB-KW
  3. membrane Source: UniProtKB-KW
  4. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host cytoplasmSAAS annotation, Host cytoplasmic vesicleSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6969capsid VP4ImportedPRO_5000381452Add
BLAST
Chaini70 – 341272capsid VP2ImportedPRO_5000381453Add
BLAST
Chaini342 – 579238capsid VP3ImportedPRO_5000381454Add
BLAST
Chaini580 – 881302capsid VP1ImportedPRO_5000381455Add
BLAST
Chaini882 – 1030149protease 2AImportedPRO_5000381456Add
BLAST
Chaini1031 – 112797protein 2BImportedPRO_5000381457Add
BLAST
Chaini1128 – 1456329ATPase 2CImportedPRO_5000381458Add
BLAST
Chaini1457 – 154387protein 3AImportedPRO_5000381459Add
BLAST
Chaini1544 – 156522protein 3BImportedPRO_5000381460Add
BLAST
Chaini1566 – 1748183protease 3CImportedPRO_5000381461Add
BLAST
Chaini1749 – 2209461polymerase 3DImportedPRO_5000381462Add
BLAST

Keywords - PTMi

PhosphoproteinSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OL6X-ray2.50A/E/I/M1749-2209[»]
3OL8X-ray2.75A/E/I/M1749-2209[»]
3OL9X-ray2.25A/E/I/M1749-2209[»]
3OLAX-ray2.55A/E/I/M1749-2209[»]
3OLBX-ray2.41A/E/I/M1749-2209[»]
ProteinModelPortaliB3VQP5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiB3VQP5.

Family & Domainsi

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotation
Contains SF3 helicase domain.SAAS annotation
Contains SFhelicase domain.SAAS annotation

Family and domain databases

Gene3Di2.60.120.20. 3 hits.
4.10.80.10. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR014838. P3A.
IPR000081. Peptidase_C3.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR003138. Pico_P1A.
IPR002527. Pico_P2B.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF08727. P3A. 1 hit.
PF00548. Peptidase_C3. 1 hit.
PF02226. Pico_P1A. 1 hit.
PF00947. Pico_P2A. 1 hit.
PF01552. Pico_P2B. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 3 hits.
PF00910. RNA_helicase. 1 hit.
[Graphical view]
ProDomiPD001306. Peptidase_C3. 1 hit.
PD649346. Pico_P2B. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF89043. SSF89043. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3VQP5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAQVSSQKV GAHENSNRAY GGSTINYTTI NYYRDSASNA ASKQDFAQDP
60 70 80 90 100
SKFTEPIKDV LIKTSPMLNS PNIEACGYSD RVLQLTLGNS TITTQEAANS
110 120 130 140 150
VVAYGRWPEY LRDSEANPVD QPTEPDVAAC RFYTLDTVSW TKESRGWWWK
160 170 180 190 200
LPDALRDMGL FGQNMYYHYL GRSGYTVHVQ CNASKFHQGA LGVFAVPEMC
210 220 230 240 250
LAGDSNTTNI YTSYQNANPG ERGGTFTNTF TPDNNQESPA RKFCPVDYLF
260 270 280 290 300
GNGTLLGNAF VFPHQIINLR TNNCATLVLP YVNSLSIDSM AKHNNWGIAI
310 320 330 340 350
LPLAPLNFAS ESSPEIPITL TIAPMCCEFN GLRNITLPRL QGLPVMNTPG
360 370 380 390 400
SNQYLTADNF QSPCALPEFD VTPPIDIPGE VKNMMELAEI DTMIPFDLSA
410 420 430 440 450
TKKNTMEMYR VRLSDKPHTD DPILCLSLSP ASDPRLSHTM LGEILNYYTH
460 470 480 490 500
WAGSLKFTFL FCGSMMATGK LLVSYAPPGA DPPKKRKEAM LGTHVIWDIG
510 520 530 540 550
LQSSCTMVVP WISNTTYRQT IDDSFTEGGY ISVFYQTRIV VPLSTPREMD
560 570 580 590 600
ILGFVSACND FSVRLLRDTT HIEQKALAQG LGQMLESMID NTVRETVGAA
610 620 630 640 650
TSRDALPNTE ASGPAHSKEI PALTAVETGA TNPLVPSDTV QTRHVVQHRS
660 670 680 690 700
RSESSIESFF ARGACVAILT VDNSASTKNN DKLFAVWKIT YKDTVQLRRK
710 720 730 740 750
LEFFTYSRFD MEFTFVVTAN FTETNNGHAL NQVYQIMYVP PGAPVPGKWD
760 770 780 790 800
DYTWQTSSNP SIFYTYGTAP ARISVPYVGI SNAYSHFYDG FSKIPLKDQS
810 820 830 840 850
AALGDSLYGA ASLNDFGILA VRVVNDHNPT KVTSKIRVYL KPKHIRVWCP
860 870 880 890 900
RPPRAVAYYG PGVDYKDGTL TPLPTKDLTT YGFGHQNKAV YTAGYKICNY
910 920 930 940 950
HLATQEDLQN AVNVMWDRDL LVTESRAQGT DSIARCNCNA GVYYCESRRK
960 970 980 990 1000
YYPVSFVGPT FQYMEANDYY PARYQSHMLI GHGFASPGDC GGILRCNHGV
1010 1020 1030 1040 1050
IGIITAGGEG LVAFSDIRDL YAYEEEAMEQ GITNYIESLG AAFGSGFTQQ
1060 1070 1080 1090 1100
IGDKITELTN MVTSTITEKL LKNLIKIISS LVIITRNYED TTTVLATLAL
1110 1120 1130 1140 1150
LGCDASPWQW LRKKACDILE IPYVIKQGDS WLKKFTEACN AAKGLEWVSN
1160 1170 1180 1190 1200
KISKFIDWLK EKIIPQARDK LEFVTKLKQL EMLENQISTI HQSCPSQEHQ
1210 1220 1230 1240 1250
EILFNNVRWL SIQSKRFAPL YAVEAKRIQK LEHTINNYIQ FKSKHRIEPV
1260 1270 1280 1290 1300
CLLVHGSPGT GKSVATNLIA RAIAERENTS TYSLPPDPSH FDGYKQQGVV
1310 1320 1330 1340 1350
IMDDLNQNPD GADMKLFCQM VSTVEFIPPM ASLEEKGILF TSNYVLASTN
1360 1370 1380 1390 1400
SSRISPPTVA HSDALARRFA FDMDIQVMNE YSRDGKLNMA MATEMCKNCH
1410 1420 1430 1440 1450
QPANFKRCCP LVCGKAIQLM DKSSRVRYSI DQITTMIINE RNRRSNIGNC
1460 1470 1480 1490 1500
MEALFQGPLQ YKDLKIDIKT SPPPECINDL LQAVDSQEVR DYCEKKGWIV
1510 1520 1530 1540 1550
NITSQVQTER NINRAMTILQ AVTTFAAVAG VVYVMYKLFA GHQGAYTGLP
1560 1570 1580 1590 1600
NKKPNVPTIR TAKVQGPGFD YAVAMAKRNI VTATTSKGEF TMLGVHDNVA
1610 1620 1630 1640 1650
ILPTHASPGE SIVIDGKEVE ILDAKALEDQ AGTNLEITII TLKRNEKFRD
1660 1670 1680 1690 1700
IRPHIPTQIT ETNDGVLIVN TNKYPNMYVP VGAVTEQGYL NLGGRQTART
1710 1720 1730 1740 1750
LMYNFPTRAG QCGGVITCTG KVIGMHVGGN GSHGFAAALK RSYFTQSQGE
1760 1770 1780 1790 1800
IQWMRPSKEV GYPIINAPSK TKLEPSAFHY VFEGVKEPAV LTKNDPRLKT
1810 1820 1830 1840 1850
DFEEAIFSKY VGNKITEVDE YMKEAVDHYA GQLMSLDINT EQMCLEDAMY
1860 1870 1880 1890 1900
GTDGLEALDL STSAGYPYVA MGKKKRDILN KQTRDTKEMQ KLLDTYGINL
1910 1920 1930 1940 1950
PLVTYVKDEL RSKTKVEQGK SRLIEASSLN DSVAMRMAFG NLYAAFHKNP
1960 1970 1980 1990 2000
GVITGSAVGC DPDLFWSKIP VLMEEKLFAF DYTGYDASLS PAWFEALKMV
2010 2020 2030 2040 2050
LEKIGFGDRV DYIDYLNHSH HLYKNKTYCV KGGMPSGCSG TSIFNSMINN
2060 2070 2080 2090 2100
LIIRTLLLKT YKGIDLDHLK MIAYGDDVIA SYPHEVDASL LAQSGKDYGL
2110 2120 2130 2140 2150
TMTPADKSAT FETVTWENVT FLKRFFRADE KYPFLIHPVM PMKEIHESIR
2160 2170 2180 2190 2200
WTKDPRNTQD HVRSLCLLAW HNGEEEYNKF LAKIRSVPIG RALLLPEYST

LYRRWLDSF
Length:2,209
Mass (Da):246,506
Last modified:September 2, 2008 - v1
Checksum:i600D35C305FA54F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794964 Genomic RNA. Translation: ACF16830.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794964 Genomic RNA. Translation: ACF16830.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3OL6 X-ray 2.50 A/E/I/M 1749-2209 [» ]
3OL8 X-ray 2.75 A/E/I/M 1749-2209 [» ]
3OL9 X-ray 2.25 A/E/I/M 1749-2209 [» ]
3OLA X-ray 2.55 A/E/I/M 1749-2209 [» ]
3OLB X-ray 2.41 A/E/I/M 1749-2209 [» ]
ProteinModelPortali B3VQP5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei B3VQP5.

Family and domain databases

Gene3Di 2.60.120.20. 3 hits.
4.10.80.10. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR014838. P3A.
IPR000081. Peptidase_C3.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR003138. Pico_P1A.
IPR002527. Pico_P2B.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view ]
Pfami PF08727. P3A. 1 hit.
PF00548. Peptidase_C3. 1 hit.
PF02226. Pico_P1A. 1 hit.
PF00947. Pico_P2A. 1 hit.
PF01552. Pico_P2B. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 3 hits.
PF00910. RNA_helicase. 1 hit.
[Graphical view ]
ProDomi PD001306. Peptidase_C3. 1 hit.
PD649346. Pico_P2B. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF89043. SSF89043. 1 hit.
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Changes in population dynamics during long-term evolution of sabin type 1 poliovirus in an immunodeficient patient."
    Odoom J.K., Yunus Z., Dunn G., Minor P.D., Martin J.
    J. Virol. 82:9179-9190(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A649Imported.
  2. "Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase."
    Gong P., Peersen O.B.
    Proc. Natl. Acad. Sci. U.S.A. 107:22505-22510(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 1749-2209 IN COMPLEX WITH MANGANESE AND ZINC.

Entry informationi

Entry nameiB3VQP5_9ENTO
AccessioniPrimary (citable) accession number: B3VQP5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3