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Protein

Estrogen receptor

Gene

Esr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Lipid-binding, Metal-binding, Steroid-bindingUniRule annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptorUniRule annotation
Short name:
ERUniRule annotation
Alternative name(s):
ER-alphaUniRule annotation
Estradiol receptorUniRule annotation
Nuclear receptor subfamily 3 group A member 1UniRule annotation
Gene namesi
Name:Esr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1352467. Esr1.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000019768.

Interactioni

Subunit structurei

Binds DNA as a homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070070.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 258Nuclear receptor DNA-bindingInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOVERGENiHBG108344.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR024736. Oestrogen-typ_rcpt_final_C_dom.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12743. ESR1_C. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00543. OESTROGENR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3VQI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKMPMERALG EVYVDNSKPT
60 70 80 90 100
VFNYPEGAAY EFNAAAAAAS APVYGQSGIA YGPGSEAAAF SANSLGAFPQ
110 120 130 140 150
LNSVSPSPLM LLHPPPQLSP FLHPHGQQVP YYLENEPSAY AVRDTGPPAF
160 170 180 190 200
YRSNSDNRRQ NGRERLSSSN EKGNMIMESA KETRYCAVCN DYASGYHYGV
210 220 230 240 250
WSCEGCKAFF KRSIQGHNDY MCPATNQCTI DKNRRKSCQA CRLRKCYEVG
260 270 280 290 300
MMKGGIRKDR RGGRMLKHKR QRDDLEGRNE MGASGDMRAA NLWPSPLVIK
310 320 330 340 350
HTKKNSPALS LTADQMVSAL LDAEPPMIYS EYDPSRPFSE ASMMGLLTNL
360 370 380 390 400
ADRELVHMIN WAKRVPGFGD LNLHDQVHLL ECAWLEILMI GLVWRSMEHP
410 420 430 440 450
GKLLFAPNLL LDRNQGKCVE GMVEIFDMLL ATSSRFRMMN LQGEEFVCLK
460 470 480 490 500
SIILLNSGVY TFLSSTLKSL EEKDHIHRVL DKITDTLIHL MAKAGLTLQQ
510 520 530 540 550
QHRRLAQLLL ILSHIRHMSN KGMEHLYNMK CKNVVPLYDL LLEMLDAHRL
560 570 580 590
HAPASRMGVP PEEPSQTQLA TTSSTSAHSL QTYYIPPEAE GFPNTI
Length:596
Mass (Da):66,742
Last modified:September 2, 2008 - v1
Checksum:iBFD8E0C671556B05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU791538 mRNA. Translation: ACF17956.1.
EU791540 mRNA. Translation: ACF17958.1.
UniGeneiMm.463262.
Mm.489063.
Mm.9213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU791538 mRNA. Translation: ACF17956.1.
EU791540 mRNA. Translation: ACF17958.1.
UniGeneiMm.463262.
Mm.489063.
Mm.9213.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1352467. Esr1.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOVERGENiHBG108344.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019768.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR024736. Oestrogen-typ_rcpt_final_C_dom.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12743. ESR1_C. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00543. OESTROGENR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3VQI7_MOUSE
AccessioniPrimary (citable) accession number: B3VQI7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.