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Protein

Estrogen receptor

Gene

Esr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi183 – 258Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandLipid-binding, Metal-binding, Steroid-bindingUniRule annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptorUniRule annotation
Short name:
ERUniRule annotation
Alternative name(s):
ER-alphaUniRule annotation
Estradiol receptorUniRule annotation
Nuclear receptor subfamily 3 group A member 1UniRule annotation
Gene namesi
Name:Esr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1352467 Esr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Binds DNA as a homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 258Nuclear receptorInterPro annotationAdd BLAST76
Domaini312 – 548NR LBDInterPro annotationAdd BLAST237

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOVERGENiHBG108344

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001292 Oestr_rcpt
IPR024736 Oestrogen-typ_rcpt_final_C_dom
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12743 ESR1_C, 1 hit
PF00104 Hormone_recep, 1 hit
PF02159 Oest_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500101 ER-a, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00543 OESTROGENR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 2 hits
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

B3VQI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKMPMERALG EVYVDNSKPT
60 70 80 90 100
VFNYPEGAAY EFNAAAAAAS APVYGQSGIA YGPGSEAAAF SANSLGAFPQ
110 120 130 140 150
LNSVSPSPLM LLHPPPQLSP FLHPHGQQVP YYLENEPSAY AVRDTGPPAF
160 170 180 190 200
YRSNSDNRRQ NGRERLSSSN EKGNMIMESA KETRYCAVCN DYASGYHYGV
210 220 230 240 250
WSCEGCKAFF KRSIQGHNDY MCPATNQCTI DKNRRKSCQA CRLRKCYEVG
260 270 280 290 300
MMKGGIRKDR RGGRMLKHKR QRDDLEGRNE MGASGDMRAA NLWPSPLVIK
310 320 330 340 350
HTKKNSPALS LTADQMVSAL LDAEPPMIYS EYDPSRPFSE ASMMGLLTNL
360 370 380 390 400
ADRELVHMIN WAKRVPGFGD LNLHDQVHLL ECAWLEILMI GLVWRSMEHP
410 420 430 440 450
GKLLFAPNLL LDRNQGKCVE GMVEIFDMLL ATSSRFRMMN LQGEEFVCLK
460 470 480 490 500
SIILLNSGVY TFLSSTLKSL EEKDHIHRVL DKITDTLIHL MAKAGLTLQQ
510 520 530 540 550
QHRRLAQLLL ILSHIRHMSN KGMEHLYNMK CKNVVPLYDL LLEMLDAHRL
560 570 580 590
HAPASRMGVP PEEPSQTQLA TTSSTSAHSL QTYYIPPEAE GFPNTI
Length:596
Mass (Da):66,742
Last modified:September 2, 2008 - v1
Checksum:iBFD8E0C671556B05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU791538 mRNA Translation: ACF17956.1
EU791540 mRNA Translation: ACF17958.1
UniGeneiMm.463262
Mm.489063
Mm.9213

Similar proteinsi

Entry informationi

Entry nameiB3VQI7_MOUSE
AccessioniPrimary (citable) accession number: B3VQI7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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