Nitric oxide synthase - Homo sapiens (Human)

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B3VK56 (B3VK56_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 36. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Nitric oxide synthase PIRNR PIRNR000333
EC=1.14.13.39 PIRNR PIRNR000333

Gene names

Name:	NOS1 EMBL EAW98110.1
ORF Names:	hCG_40354 EMBL EAW98110.1

Organism

Homo sapiens (Human) EMBL ACF04132.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1434 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Produces nitric oxide (NO) By similarity. PIRNR PIRNR000333
Catalytic activity	L-arginine + n NADPH + n H⁺ + m O₂ = citrulline + nitric oxide + n NADP⁺. PIRNR PIRNR000333
Cofactor	Binds 1 FAD By similarity. PIRNR PIRNR000333 Binds 1 FMN By similarity. PIRNR PIRNR000333 Heme group By similarity. PIRNR PIRNR000333
Sequence similarities	Belongs to the NOS family. PIRNR PIRNR000333 Contains 1 PDZ (DHR) domain. RuleBase RU003354

Ontologies

Keywords
Ligand	Calmodulin-binding PIRNR PIRNR000333 FAD PIRNR PIRNR000333 FMN PIRNR PIRNR000333 Heme PIRNR PIRNR000333 Iron Metal-binding NADP PIRNR PIRNR000333
Molecular function	Oxidoreductase PIRNR PIRNR000333
Gene Ontology (GO)
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro NADP binding Inferred from electronic annotation. Source: InterPro calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro nitric-oxide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

B3VK56 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 99235793B953BF37
Show »

FASTA

1,434

160,970

        10         20         30         40         50         60 
MEDHMFGVQQ IQPNVISVRL FKRKVGGLGF LVKERVSKPP VIISDLIRGG AAEQSGLIQA 

        70         80         90        100        110        120 
GDIILAVNGR PLVDLSYDSA LEVLRGIASE THVVLILRGP EGFTTHLETT FTGDGTPKTI 

       130        140        150        160        170        180 
RVTQPLGPPT KAVDLSHQPP AGKEQPLAVD GASGPGNGPQ HAYDDGQEAG SLPHANGLAP 

       190        200        210        220        230        240 
RPPGQDPAKK ATRVSLQGRG ENNELLKEIE PVLSLLTSGS RGVKGGAPAK AEMKDMGIQV 

       250        260        270        280        290        300 
DRDLDGKSHK PLPLGVENDR VFNDLWGKGN VPVVLNNPYS EKEQPPTSGK QSPTKNGSPS 

       310        320        330        340        350        360 
KCPRFLKVKN WETEVVLTDT LHLKSTLETG CTEYICMGSI MHPSQHARRP EDVRTKGQLF 

       370        380        390        400        410        420 
PLAKEFIDQY YSSIKRFGSK AHMERLEEVN KEIDTTSTYQ LKDTELIYGA KHAWRNASRC 

       430        440        450        460        470        480 
VGRIQWSKLQ VFDARDCTTA HGMFNYICNH VKYATNKGNL RSAITIFPQR TDGKHDFRVW 

       490        500        510        520        530        540 
NSQLIRYAGY KQPDGSTLGD PANVQFTEIC IQQGWKPPRG RFDVLPLLLQ ANGNDPELFQ 

       550        560        570        580        590        600 
IPPELVLEVP IRHPKFEWFK DLGLKWYGLP AVSNMLLEIG GLEFSACPFS GWYMGTEIGV 

       610        620        630        640        650        660 
RDYCDNSRYN ILEEVAKKMN LDMRKTSSLW KDQALVEINI AVLYSFQSDK VTIVDHHSAT 

       670        680        690        700        710        720 
ESFIKHMENE YRCRGGCPAD WVWIVPPMSG SITPVFHQEM LNYRLTPSFE YQPDPWNTHV 

       730        740        750        760        770        780 
WKGTNGTPTK RRAIGFKKLA EAVKFSAKLM GQAMAKRVKA TILYATETGK SQAYAKTLCE 

       790        800        810        820        830        840 
IFKHAFDAKV MSMEEYDIVH LEHETLVLVV TSTFGNGDPP ENGEKFGCAL MEMRHPNSVQ 

       850        860        870        880        890        900 
EERKSYKVRF NSVSSYSDSQ KSSGDGPDLR DNFESAGPLA NVRFSVFGLG SRAYPHFCAF 

       910        920        930        940        950        960 
GHAVDTLLEE LGGERILKMR EGDELCGQEE AFRTWAKKVF KAACDVFCVG DDVNIEKANN 

       970        980        990       1000       1010       1020 
SLISNDRSWK RNKFRLTFVA EAPELTQGLS NVHKKRVSAA RLLSRQNLQS PKSSRSTIFV 

      1030       1040       1050       1060       1070       1080 
RLHTNGSQEL QYQPGDHLGV FPGNHEDLVN ALIERLEDAP PVNQMVKVEL LEERNTALGV 

      1090       1100       1110       1120       1130       1140 
ISNWTDELRL PPCTIFQAFK YYLDITTPPT PLQLQQFASL ATSEKEKQRL LVLSKGLQEY 

      1150       1160       1170       1180       1190       1200 
EEWKWGKNPT IVEVLEEFPS IQMPATLLLT QLSLLQPRYY SISSSPDMYP DEVHLTVAIV 

      1210       1220       1230       1240       1250       1260 
SYRTRDGEGP IHHGVCSSWL NRIQADELVP CFVRGAPSFH LPRNPQVPCI LVGPGTGIAP 

      1270       1280       1290       1300       1310       1320 
FRSFWQQRQF DIQHKGMNPC PMVLVFGCRQ SKIDHIYREE TLQAKNKGVF RELYTAYSRE 

      1330       1340       1350       1360       1370       1380 
PDKPKKYVQD ILQEQLAESV YRALKEQGGH IYVCGDVTMA ADVLKAIQRI MTQQGKLSAE 

      1390       1400       1410       1420       1430 
DAGVFISRMR DDNRYHEDIF GVTLRTYEVT NRLRSESIAF IEESKKDTDE VFSS

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Cross-references

Sequence databases
EMBL GenBank DDBJ	EU753241 mRNA. Translation: ACF04132.1. CH471054 Genomic DNA. Translation: EAW98110.1.
IPI	IPI00217225.
RefSeq	NP_000611.1. NM_000620.4.
UniGene	Hs.654410. Hs.684465. Hs.684466. Hs.684467.
3D structure databases
ProteinModelPortal	B3VK56.
SMR	B3VK56. Positions 12-126, 303-721, 755-1418.
ModBase	Search...
Protein-protein interaction databases
STRING	B3VK56.
Proteomic databases
PRIDE	B3VK56.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4842.
KEGG	hsa:4842.
Organism-specific databases
CTD	4842.
Phylogenomic databases
HOVERGEN	HBG000159.
PhylomeDB	B3VK56.
Gene expression databases
Bgee	B3VK56.
Family and domain databases
InterPro	IPR003097. FAD-binding_1. IPR017927. Fd_Rdtase_FAD-bd. IPR001094. Flavdoxin. IPR008254. Flavodoxin/NO_synth. IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase. IPR023173. NADPH_Cyt_P450_Rdtase_dom3. IPR012144. Nitric-oxide_synthase. IPR004030. NO_synthase_oxygenase_dom. IPR001433. OxRdtase_FAD/NAD-bd. IPR001478. PDZ/DHR/GLGF. IPR017938. Riboflavin_synthase-like_b-brl. [Graphical view]
Gene3D	G3DSA:1.20.990.10. NADPH_Cyt_P450_Rdtase_dom3. 1 hit. G3DSA:3.90.340.10. NO_synthase_oxygenase_reg. 1 hit.
KO	K13240.
PANTHER	PTHR19384:SF5. PTHR19384:SF5. 1 hit.
Pfam	PF00667. FAD_binding_1. 1 hit. PF00258. Flavodoxin_1. 1 hit. PF00175. NAD_binding_1. 1 hit. PF02898. NO_synthase. 1 hit. PF00595. PDZ. 1 hit. [Graphical view]
PIRSF	PIRSF000333. NOS. 1 hit.
PRINTS	PR00369. FLAVODOXIN. PR00371. FPNCR.
SMART	SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF56512. NO_synthase_oxygenase_reg. 1 hit. SSF50156. PDZ. 1 hit. SSF63380. Riboflavin_synthase_like_b-brl. 1 hit.
PROSITE	PS51384. FAD_FR. 1 hit. PS50902. FLAVODOXIN_LIKE. 1 hit. PS60001. NOS. 1 hit. PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B3VK56_HUMAN

Accession

Primary (citable) accession number: B3VK56

Entry history

Integrated into UniProtKB/TrEMBL:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

[1]	"NOS1 missense mutation." Malacrida S., Danieli G.A. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information