Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisUniRule annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Virion membrane SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalUniRule annotationAdd BLAST22
Transmembranei573 – 600HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotation, Host endosomeUniRule annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationImported, Virion

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 503GP120InterPro annotationAdd BLAST471
Domaini498 – 614GP41InterPro annotationAdd BLAST117

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiView protein in InterPro
IPR036377. Gp120_core_sf.
IPR000328. GP41-like.
IPR000777. HIV1_Gp120.
PfamiView protein in Pfam
PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3US36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVKGIRKNY QHLWKWGIML LGILMICSAA ENLWVTVYYG VPVWKEATIT
60 70 80 90 100
LFCASDAKAY DTEVHNVWAT HACVPTDPNP QEVVLENVTE NFNMWKNNMV
110 120 130 140 150
EQMHEDIISL WDQSLKPCVK LTPLCVTLNC TNVNVTNLKN ETNTNSSSGG
160 170 180 190 200
EKMEEGEMKN CSFNVTTLIR NKRKTEYALF YKLDVMPIDH DNTSYTLINC
210 220 230 240 250
NSSTITQACP KVSFEPIPIH YCAPAGFAIL KCNDKKFNGK GPCKNVSTVQ
260 270 280 290 300
CTHGIRPVVS TQLLLNGSLA EEDIVIRSEN FTDNAKNIIV QLNVSIEINC
310 320 330 340 350
TRPNNNTRKK ITLGPGRVLY TTGEIIGDIR RAHCNLSRTS WNNTLKQIVE
360 370 380 390 400
KLREIKQFKN KTIVFKQSSG GDPEIVMHSF NCGGEFFYCN STQLFNSTWH
410 420 430 440 450
ANGTWKNTEG ADNNITLPCR IKQIINRWQE VGKAMYAPPI EGQIRCLSNI
460 470 480 490 500
TGLLLTRDGG SSEENQTEIF RPGGGNMKDN WRSELYKYKV VKIEPLGVAT
510 520 530 540 550
TTVPWNASWS NRSQDYIWNN MTWMEWEREI NNYTGLIYNL IEESQNQQEK
560 570 580 590 600
NEQELLELDK WAGLWTWFDI SNWLWYIKIF IMIVGGLIGL RIVFTVLSIV
610 620 630 640 650
NRVRQGYSPL SFQTHLPAPR GPDRPEGIEE EGGERDRDRS GRLVDGFLTL
660 670 680 690 700
IWVDLRSLCL FLYHRLIDLL LIAKRIVELL GRRGWEALKY CWNLLQYWSQ
710 720 730 740 750
ELKNSAVSLL NATAIAVAEG TDRVIEIVQR TCRAILHIPR RIRQGLERAL

L
Length:751
Mass (Da):85,979
Last modified:September 2, 2008 - v1
Checksum:i26D6193F774730CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU577351 Genomic RNA. Translation: ACE71445.1.

Similar proteinsi

Entry informationi

Entry nameiB3US36_9HIV1
AccessioniPrimary (citable) accession number: B3US36
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: October 25, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation