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B3TMR1

- B3TMR1_9ACTO

UniProt

B3TMR1 - B3TMR1_9ACTO

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Protein
Submitted name: FAD-dependent oxidoreductase
Gene
KijD3
Organism
Actinomadura kijaniata
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei171 – 1711FMNImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi141 – 1433FMNImported
Nucleotide bindingi383 – 3853FMNImported

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Ligandi

    FADUniRule annotation, Flavoprotein, FMNImported, Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    FAD-dependent oxidoreductaseImported
    Gene namesi
    ORF Names:KijD3Imported
    OrganismiActinomadura kijaniataImported
    Taxonomic identifieri46161 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeThermomonosporaceaeActinomadura

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3M9VX-ray2.05A1-437[»]
    4KCFX-ray2.10A1-437[»]

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acyl-CoA dehydrogenase family.UniRule annotation

    Family and domain databases

    Gene3Di1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF02771. Acyl-CoA_dh_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47203. SSF47203. 1 hit.
    SSF56645. SSF56645. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3TMR1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPWTARQDS TTGLYAPVTP AGRVLLDRLA AHLPRIRSTA AEHDRDGTFP    50
    TDTFDALRKD GLMGATVPAE LGGLGVDRLY DVAVALLAVA RADASTALAL 100
    HMQLSRGLTL GYEWRHGDER ARTLAERILR GMVAGDAVVC SGIKDHHTAV 150
    TTLRPDGAGG WLLSGRKTLV SMAPVGTHFV INARTDGTDG PPRLASPVVT 200
    RDTPGFTVLD NWDGLGMRAS GTVDIVFDDC PIPADHVLMR DPVGARNDAV 250
    LAGQTVSSVS VLGVYVGVAQ AAYDTAVAAL ERRPEPPQAA ALTLVAEIDS 300
    RLYALRATAG SALTAADALS ADLSGDMDER GRQMMRHFQC AKLAVNRLAP 350
    EIVSDCLSLV GGASYTAGHP LARLLRDVQA GRFMQPYAYV DAVDFLSAQA 400
    LGIERDNNYM STWAKRSGGN GKSADAAGPR RPTPTSR 437
    Length:437
    Mass (Da):46,240
    Last modified:September 2, 2008 - v1
    Checksum:i5ACFDC5E754820DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU301739 Genomic DNA. Translation: ACB46491.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU301739 Genomic DNA. Translation: ACB46491.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3M9V X-ray 2.05 A 1-437 [» ]
    4KCF X-ray 2.10 A 1-437 [» ]
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProi IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF02771. Acyl-CoA_dh_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47203. SSF47203. 1 hit.
    SSF56645. SSF56645. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars."
      Zhang H., White-Phillip J.A., Melancon C.E., Kwon H.-J., Yu W.-L., Liu H.-W.
      J. Am. Chem. Soc. 129:14670-14683(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "X-ray structure of kijd3, a key enzyme involved in the biosynthesis of D-kijanose."
      Bruender N.A., Thoden J.B., Holden H.M.
      Biochemistry 49:3517-3524(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).
    3. "Active site architecture of a sugar N-oxygenase."
      Thoden J.B., Branch M.C., Zimmer A.L., Bruender N.A., Holden H.M.
      Biochemistry 52:3191-3193(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH FMN.

    Entry informationi

    Entry nameiB3TMR1_9ACTO
    AccessioniPrimary (citable) accession number: B3TMR1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: June 11, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3

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