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Protein

Non-structural protein 6

Gene
N/A
Organism
Rotavirus A (strain Human/United States/DS-1/1976 G2-P1B[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2) (RV-A) (Rotavirus A (strain DS1))
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 6
Short name:
NSP6
OrganismiRotavirus A (strain Human/United States/DS-1/1976 G2-P1B[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2) (RV-A) (Rotavirus A (strain DS1))
Taxonomic identifieri10950 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000001457 Componenti: Genome

Subcellular locationi

  1. Host cytoplasm

  2. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.By similarity

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Non-structural protein 6PRO_0000369523Add
BLAST

Interactioni

Subunit structurei

Interacts with NSP5.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus A NSP6 family.Curated

Family and domain databases

InterProiIPR006950. Rotavirus_NSP6.
[Graphical view]
PfamiPF04866. Rota_NS6. 1 hit.
[Graphical view]
ProDomiPD008065. Rota_NS6. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

B3SRT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRLQQRQLF LENLLVGVNS TFHQMQKLSI NTCCQNLQKI LDLLILHRTI
60 70 80 90
HSPAFRLDRM QLRQMQMLAC LWIHQRNHDH LATLDTIKWI SP
Length:92
Mass (Da):11,014
Last modified:September 2, 2008 - v1
Checksum:i33748C9C39421F9E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301I → E (PubMed:2152809).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33608 Genomic RNA. Translation: AAA47327.1.
EF672583 Genomic RNA. Translation: ABV53259.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33608 Genomic RNA. Translation: AAA47327.1.
EF672583 Genomic RNA. Translation: ABV53259.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR006950. Rotavirus_NSP6.
[Graphical view]
PfamiPF04866. Rota_NS6. 1 hit.
[Graphical view]
ProDomiPD008065. Rota_NS6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of gene 11 equivalents from 'short' and 'super short' strains of rotavirus."
    Matsui S.M., Mackow E.R., Matsuno S., Paul P.S., Greenberg H.B.
    J. Virol. 64:120-124(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Group A human rotavirus genomics: evidence that gene constellations are influenced by viral protein interactions."
    Heiman E.M., McDonald S.M., Barro M., Taraporewala Z.F., Bar-Magen T., Patton J.T.
    J. Virol. 82:11106-11116(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP6_ROTHD
AccessioniPrimary (citable) accession number: B3SRT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: January 7, 2015
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.