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B3SBB5

- LIAS_TRIAD

UniProt

B3SBB5 - LIAS_TRIAD

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Protein

Lipoyl synthase, mitochondrial

Gene

TRIADDRAFT_38449

Organism
Trichoplax adhaerens (Trichoplax reptans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Iron-sulfur 1 (4Fe-4S)UniRule annotation
Metal bindingi88 – 881Iron-sulfur 1 (4Fe-4S)UniRule annotation
Metal bindingi94 – 941Iron-sulfur 1 (4Fe-4S)UniRule annotation
Metal bindingi113 – 1131Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
Metal bindingi117 – 1171Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
Metal bindingi120 – 1201Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, mitochondrialUniRule annotation (EC:2.8.1.8UniRule annotation)
Alternative name(s):
Lipoate synthaseUniRule annotation
Short name:
LSUniRule annotation
Short name:
Lip-synUniRule annotation
Lipoic acid synthaseUniRule annotation
Gene namesi
ORF Names:TRIADDRAFT_38449
OrganismiTrichoplax adhaerens (Trichoplax reptans)
Taxonomic identifieri10228 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlacozoaTrichoplax
ProteomesiUP000009022: Unassembled WGS sequence

Subcellular locationi

Mitochondrion UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 350Lipoyl synthase, mitochondrialPRO_0000398298
Transit peptidei1 – ?MitochondrionUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi10228.JGI38449.

Structurei

3D structure databases

ProteinModelPortaliB3SBB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the radical SAM superfamily. Lipoyl synthase family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0320.
HOGENOMiHOG000235998.
InParanoidiB3SBB5.
KOiK03644.
OMAiHPHIPTK.
OrthoDBiEOG7P2XS7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3SBB5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSTVASIRD YSNIPKSKRE EIANGPGLED FIVKSPTSLN TLFIYYSNFS
60 70 80 90 100
LPLPPWLKTT IPTSNSYNKL NKDLRNLKLH TVCEEARCPN IGECWGGESG
110 120 130 140 150
TATATIMVLG DTCTRGCRFC SVKTARKPPP PDPDEPVNTA IALAQWGLDY
160 170 180 190 200
VVLTSVDRDD LSDGGSNHFA ETVKEIKKRN LSMLVETLTP DFRGDKAAIA
210 220 230 240 250
TVVNAGVDVY AHNVETVKNL QWLVRDPRAN YEQSLEVLSY AKIVNPNLVT
260 270 280 290 300
KTSIMLGLGE TDESILQTMK DLRSIDVDCI TLGQYMQPTR YHIKVKEYVT
310 320 330 340 350
PAKFQHWEKV GNELGFAYTA SGPLVRSSYK AGEFYLKNLV HKRNKTNGSD
Length:350
Mass (Da):38,945
Last modified:September 2, 2008 - v1
Checksum:i6DAE3B6F9A2227DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985264 Genomic DNA. Translation: EDV19926.1.
RefSeqiXP_002117516.1. XM_002117480.1.

Genome annotation databases

EnsemblMetazoaiTriadT38449; TriadP38449; TriadG38449.
GeneIDi6758779.
KEGGitad:TRIADDRAFT_38449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985264 Genomic DNA. Translation: EDV19926.1 .
RefSeqi XP_002117516.1. XM_002117480.1.

3D structure databases

ProteinModelPortali B3SBB5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10228.JGI38449.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai TriadT38449 ; TriadP38449 ; TriadG38449 .
GeneIDi 6758779.
KEGGi tad:TRIADDRAFT_38449.

Phylogenomic databases

eggNOGi COG0320.
HOGENOMi HOG000235998.
InParanoidi B3SBB5.
KOi K03644.
OMAi HPHIPTK.
OrthoDBi EOG7P2XS7.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Grell-BS-1999.

Entry informationi

Entry nameiLIAS_TRIAD
AccessioniPrimary (citable) accession number: B3SBB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: September 2, 2008
Last modified: November 26, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3