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B3SBB5

- LIAS_TRIAD

UniProt

B3SBB5 - LIAS_TRIAD

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Protein
Lipoyl synthase, mitochondrial
Gene
TRIADDRAFT_38449
Organism
Trichoplax adhaerens (Trichoplax reptans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi88 – 881Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi94 – 941Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi113 – 1131Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi117 – 1171Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi120 – 1201Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, mitochondrial (EC:2.8.1.8)
Alternative name(s):
Lipoate synthase
Short name:
LS
Short name:
Lip-syn
Lipoic acid synthase
Gene namesi
ORF Names:TRIADDRAFT_38449
OrganismiTrichoplax adhaerens (Trichoplax reptans)
Taxonomic identifieri10228 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlacozoaTrichoplax
ProteomesiUP000009022: Unassembled WGS sequence

Subcellular locationi

Mitochondrion By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 350Lipoyl synthase, mitochondrialUniRule annotationPRO_0000398298
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Interactioni

Protein-protein interaction databases

STRINGi10228.JGI38449.

Structurei

3D structure databases

ProteinModelPortaliB3SBB5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0320.
HOGENOMiHOG000235998.
KOiK03644.
OMAiHPHIPTK.
OrthoDBiEOG7P2XS7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3SBB5-1 [UniParc]FASTAAdd to Basket

« Hide

MPSTVASIRD YSNIPKSKRE EIANGPGLED FIVKSPTSLN TLFIYYSNFS    50
LPLPPWLKTT IPTSNSYNKL NKDLRNLKLH TVCEEARCPN IGECWGGESG 100
TATATIMVLG DTCTRGCRFC SVKTARKPPP PDPDEPVNTA IALAQWGLDY 150
VVLTSVDRDD LSDGGSNHFA ETVKEIKKRN LSMLVETLTP DFRGDKAAIA 200
TVVNAGVDVY AHNVETVKNL QWLVRDPRAN YEQSLEVLSY AKIVNPNLVT 250
KTSIMLGLGE TDESILQTMK DLRSIDVDCI TLGQYMQPTR YHIKVKEYVT 300
PAKFQHWEKV GNELGFAYTA SGPLVRSSYK AGEFYLKNLV HKRNKTNGSD 350
Length:350
Mass (Da):38,945
Last modified:September 2, 2008 - v1
Checksum:i6DAE3B6F9A2227DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS985264 Genomic DNA. Translation: EDV19926.1.
RefSeqiXP_002117516.1. XM_002117480.1.

Genome annotation databases

EnsemblMetazoaiTriadT38449; TriadP38449; TriadG38449.
GeneIDi6758779.
KEGGitad:TRIADDRAFT_38449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS985264 Genomic DNA. Translation: EDV19926.1 .
RefSeqi XP_002117516.1. XM_002117480.1.

3D structure databases

ProteinModelPortali B3SBB5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10228.JGI38449.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai TriadT38449 ; TriadP38449 ; TriadG38449 .
GeneIDi 6758779.
KEGGi tad:TRIADDRAFT_38449.

Phylogenomic databases

eggNOGi COG0320.
HOGENOMi HOG000235998.
KOi K03644.
OMAi HPHIPTK.
OrthoDBi EOG7P2XS7.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Grell-BS-1999.

Entry informationi

Entry nameiLIAS_TRIAD
AccessioniPrimary (citable) accession number: B3SBB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: September 2, 2008
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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