ID   B3SAP0_TRIAD            Unreviewed;       217 AA.
AC   B3SAP0;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=SET domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=TRIADDRAFT_32357 {ECO:0000313|EMBL:EDV20136.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV20136.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV20136.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV20136.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; DS985262; EDV20136.1; -; Genomic_DNA.
DR   RefSeq; XP_002117297.1; XM_002117261.1.
DR   AlphaFoldDB; B3SAP0; -.
DR   STRING; 10228.B3SAP0; -.
DR   EnsemblMetazoa; TriadT32357; TriadP32357; TriadG32357.
DR   GeneID; 6758562; -.
DR   KEGG; tad:TRIADDRAFT_32357; -.
DR   CTD; 6758562; -.
DR   eggNOG; KOG1080; Eukaryota.
DR   HOGENOM; CLU_020840_0_2_1; -.
DR   InParanoid; B3SAP0; -.
DR   OMA; RERRYIS; -.
DR   OrthoDB; 5490909at2759; -.
DR   PhylomeDB; B3SAP0; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR   GO; GO:0042800; F:histone H3K4 methyltransferase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd19169; SET_SETD1; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR024657; COMPASS_Set1_N-SET.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR044570; Set1-like.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR037841; SET_SETD1A/B.
DR   PANTHER; PTHR45814; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR   PANTHER; PTHR45814:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR   Pfam; PF11764; N-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          78..195
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          201..217
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          25..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EDV20136.1"
SQ   SEQUENCE   217 AA;  24729 MW;  ACB08D7B965EB1CB CRC64;
     HKTGCARCEG YYRIDKADKA RHVQDAATAA AAAESNEPSK GRQVSRENRA SNRRIISFFQ
     ASDAGDLLKL NQLKTRKKQL RFGRSQIHEW GLFAREPIAA DEMVIEYVGQ TIRQTVADER
     EHRYEKIGIG SSYLFRIDDN YIIDATKCGN LARFINHSCS PNCYAKIISL ESQKKIVIYS
     KYDIQVNEEI TYDYKFPIED VKIPCHCGAL QCRGALN
//