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Protein

Histone-lysine N-methyltransferase

Gene

TRIADDRAFT_59058

Organism
Trichoplax adhaerens (Trichoplax reptans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:TRIADDRAFT_59058Imported
OrganismiTrichoplax adhaerens (Trichoplax reptans)Imported
Taxonomic identifieri10228 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlacozoaTrichoplax
Proteomesi
  • UP000009022 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi10228.TriadP59058.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 193SETInterPro annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 83S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni153 – 154S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.PROSITE-ProRule annotation
Contains 1 SET domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1085. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000020818.
InParanoidiB3S4E8.
KOiK11428.
OMAiFGCYMYY.
OrthoDBiEOG091G0UBI.

Family and domain databases

InterProiIPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3S4E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRKLLKSEN KKLPLKANGE ALKRSHPSVP PLQTKITDLF PVRRSTRKCK
60 70 80 90 100
SDLKNAEEAF MIQYILTNKE DGIQMIYTEG KGRGIVTTKP FKKGDFLCEY
110 120 130 140 150
AGELISRKEA LQREVSYGKD PNIGNYMYFF SYKGSDFCVD ATKETDRLGR
160 170 180 190 200
LVNHSRKNYN SISRLIPING NPHLVLIAYR DIGIGEELLY DYGDHSKKSI

EAHPWLEL
Length:208
Mass (Da):23,790
Last modified:September 2, 2008 - v1
Checksum:iE216A1C5BC5A82DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985249 Genomic DNA. Translation: EDV22448.1.
RefSeqiXP_002114992.1. XM_002114956.1.

Genome annotation databases

EnsemblMetazoaiTriadT59058; TriadP59058; TriadG59058.
GeneIDi6756383.
KEGGitad:TRIADDRAFT_59058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985249 Genomic DNA. Translation: EDV22448.1.
RefSeqiXP_002114992.1. XM_002114956.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10228.TriadP59058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiTriadT59058; TriadP59058; TriadG59058.
GeneIDi6756383.
KEGGitad:TRIADDRAFT_59058.

Phylogenomic databases

eggNOGiKOG1085. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000020818.
InParanoidiB3S4E8.
KOiK11428.
OMAiFGCYMYY.
OrthoDBiEOG091G0UBI.

Family and domain databases

InterProiIPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3S4E8_TRIAD
AccessioniPrimary (citable) accession number: B3S4E8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: January 18, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.