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B3S2J9

- B3S2J9_TRIAD

UniProt

B3S2J9 - B3S2J9_TRIAD

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

TRIADDRAFT_58052

Organism
Trichoplax adhaerens (Trichoplax reptans)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:TRIADDRAFT_58052Imported
OrganismiTrichoplax adhaerens (Trichoplax reptans)Imported
Taxonomic identifieri10228 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlacozoaTrichoplax
ProteomesiUP000009022: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi10228.JGI58052.

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
InParanoidiB3S2J9.
KOiK11427.
OrthoDBiEOG7W6WJV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3S2J9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHSHRLTYR RKHRNQAQEI IDTISFVCED FVELRPAMNN NIAQFYKPES
60 70 80 90 100
YESMSTMCEK YNRAIDGIRQ LVYGETSFSL MTQILKILNP TPDDVFIDLG
110 120 130 140 150
SGVGQAVLQA AASTNCKECW GIEKADIPAK FAKEIDKSFR KWMKWFGKSF
160 170 180 190 200
CKYQLVKGDF LAPEYEGLIP KCTLIFVNNF AFGPAVDHQL KQIFANLVEG
210 220 230 240 250
AKIVSSREFM PLNFRISSRN LSDIGSMMRI EELASLRGGV SWTGKPVKYY
260 270 280 290 300
LHTVDSTAEN NQTENLSSNG AKSTLSNFID DEGVDDVTVF ESGNANISFN
310 320 330 340 350
SIKTSRTCEN RQEKSQKSLL DIQKIPVLNE RNSEISKIKK RKKQHSQFSI
360 370 380 390 400
MDAKLKAGVA STDNDSEYNN LNEKVIKKLK KHQGIKLKKK EKKIKSNSIK
410 420 430 440 450
EALTSTADAE ELINNQKNRK TIKAKISSKL GKSKKRQKNA TEGSVTKNEQ
460 470 480 490 500
LLYNSSGIQN VHSDNVATLS KDVQYSGNHG AMPRSLLNKI THVNKHHHQA
510 520 530 540 550
LAGYDQILTS IAQNVTLPEF QQQLKHEHDS LLQQESELTK HLKWLKSENR
560 570 580 590 600
SLLDTNARLA DKALKEFNEI KAIVGPNVGE ISTFEPFKIN QLLSITKDST
610 620 630 640 650
NLPFNINREG RQNKISTSSD LSCTQKTNHS VIVNGTSSPR SEVQVDYEVN
660 670 680 690 700
NLHPEESQTI QKMKMSDYPD PNTFKANVNT NLLDNCEQLG AKSEPFDSKQ
710 720 730 740 750
QEKASVNDSE LKLQSGYRNH CYDVKIANGI NVSNGTTELD SNHYNECTEL
760 770 780
KTQHKSVLMN HKTPVGNNGI TENGFTTVKS CID
Length:783
Mass (Da):88,139
Last modified:September 2, 2008 - v1
Checksum:i4C90E65B91123C9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS985247 Genomic DNA. Translation: EDV23106.1.
RefSeqiXP_002114016.1. XM_002113980.1.

Genome annotation databases

EnsemblMetazoaiTriadT58052; TriadP58052; TriadG58052.
GeneIDi6755558.
KEGGitad:TRIADDRAFT_58052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS985247 Genomic DNA. Translation: EDV23106.1 .
RefSeqi XP_002114016.1. XM_002113980.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10228.JGI58052.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai TriadT58052 ; TriadP58052 ; TriadG58052 .
GeneIDi 6755558.
KEGGi tad:TRIADDRAFT_58052.

Phylogenomic databases

eggNOGi NOG294902.
InParanoidi B3S2J9.
KOi K11427.
OrthoDBi EOG7W6WJV.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Grell-BS-1999Imported.

Entry informationi

Entry nameiB3S2J9_TRIAD
AccessioniPrimary (citable) accession number: B3S2J9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3