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B3S2J9

- B3S2J9_TRIAD

UniProt

B3S2J9 - B3S2J9_TRIAD

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

TRIADDRAFT_58052

Organism
Trichoplax adhaerens (Trichoplax reptans)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:TRIADDRAFT_58052Imported
    OrganismiTrichoplax adhaerens (Trichoplax reptans)Imported
    Taxonomic identifieri10228 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlacozoaTrichoplax
    ProteomesiUP000009022: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi10228.JGI58052.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG294902.
    KOiK11427.
    OrthoDBiEOG7W6WJV.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3S2J9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHSHRLTYR RKHRNQAQEI IDTISFVCED FVELRPAMNN NIAQFYKPES    50
    YESMSTMCEK YNRAIDGIRQ LVYGETSFSL MTQILKILNP TPDDVFIDLG 100
    SGVGQAVLQA AASTNCKECW GIEKADIPAK FAKEIDKSFR KWMKWFGKSF 150
    CKYQLVKGDF LAPEYEGLIP KCTLIFVNNF AFGPAVDHQL KQIFANLVEG 200
    AKIVSSREFM PLNFRISSRN LSDIGSMMRI EELASLRGGV SWTGKPVKYY 250
    LHTVDSTAEN NQTENLSSNG AKSTLSNFID DEGVDDVTVF ESGNANISFN 300
    SIKTSRTCEN RQEKSQKSLL DIQKIPVLNE RNSEISKIKK RKKQHSQFSI 350
    MDAKLKAGVA STDNDSEYNN LNEKVIKKLK KHQGIKLKKK EKKIKSNSIK 400
    EALTSTADAE ELINNQKNRK TIKAKISSKL GKSKKRQKNA TEGSVTKNEQ 450
    LLYNSSGIQN VHSDNVATLS KDVQYSGNHG AMPRSLLNKI THVNKHHHQA 500
    LAGYDQILTS IAQNVTLPEF QQQLKHEHDS LLQQESELTK HLKWLKSENR 550
    SLLDTNARLA DKALKEFNEI KAIVGPNVGE ISTFEPFKIN QLLSITKDST 600
    NLPFNINREG RQNKISTSSD LSCTQKTNHS VIVNGTSSPR SEVQVDYEVN 650
    NLHPEESQTI QKMKMSDYPD PNTFKANVNT NLLDNCEQLG AKSEPFDSKQ 700
    QEKASVNDSE LKLQSGYRNH CYDVKIANGI NVSNGTTELD SNHYNECTEL 750
    KTQHKSVLMN HKTPVGNNGI TENGFTTVKS CID 783
    Length:783
    Mass (Da):88,139
    Last modified:September 2, 2008 - v1
    Checksum:i4C90E65B91123C9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS985247 Genomic DNA. Translation: EDV23106.1.
    RefSeqiXP_002114016.1. XM_002113980.1.

    Genome annotation databases

    EnsemblMetazoaiTriadT58052; TriadP58052; TriadG58052.
    GeneIDi6755558.
    KEGGitad:TRIADDRAFT_58052.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS985247 Genomic DNA. Translation: EDV23106.1 .
    RefSeqi XP_002114016.1. XM_002113980.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10228.JGI58052.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai TriadT58052 ; TriadP58052 ; TriadG58052 .
    GeneIDi 6755558.
    KEGGi tad:TRIADDRAFT_58052.

    Phylogenomic databases

    eggNOGi NOG294902.
    KOi K11427.
    OrthoDBi EOG7W6WJV.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Grell-BS-1999Imported.

    Entry informationi

    Entry nameiB3S2J9_TRIAD
    AccessioniPrimary (citable) accession number: B3S2J9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3