ID   B3S0P2_TRIAD            Unreviewed;       291 AA.
AC   B3S0P2;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=Inositol-tetrakisphosphate 1-kinase {ECO:0000256|ARBA:ARBA00014968};
DE            EC=2.7.1.134 {ECO:0000256|ARBA:ARBA00012072};
DE            EC=2.7.1.159 {ECO:0000256|ARBA:ARBA00012017};
DE   AltName: Full=Inositol 1,3,4-trisphosphate 5/6-kinase {ECO:0000256|ARBA:ARBA00031742};
GN   ORFNames=TRIADDRAFT_57121 {ECO:0000313|EMBL:EDV23677.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV23677.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV23677.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV23677.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR038186-2};
CC       Note=Binds 2 magnesium ions per subunit.
CC       {ECO:0000256|PIRSR:PIRSR038186-2};
CC   -!- SIMILARITY: Belongs to the ITPK1 family.
CC       {ECO:0000256|ARBA:ARBA00009601}.
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DR   EMBL; DS985246; EDV23677.1; -; Genomic_DNA.
DR   RefSeq; XP_002113203.1; XM_002113167.1.
DR   AlphaFoldDB; B3S0P2; -.
DR   STRING; 10228.B3S0P2; -.
DR   EnsemblMetazoa; TriadT57121; TriadP57121; TriadG57121.
DR   GeneID; 6754416; -.
DR   KEGG; tad:TRIADDRAFT_57121; -.
DR   CTD; 6754416; -.
DR   eggNOG; ENOG502QQS1; Eukaryota.
DR   HOGENOM; CLU_041857_1_0_1; -.
DR   InParanoid; B3S0P2; -.
DR   OMA; VGERTCC; -.
DR   OrthoDB; 180652at2759; -.
DR   PhylomeDB; B3S0P2; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0047325; F:inositol tetrakisphosphate 1-kinase activity; IBA:GO_Central.
DR   GO; GO:0052726; F:inositol-1,3,4-trisphosphate 5-kinase activity; IBA:GO_Central.
DR   GO; GO:0052725; F:inositol-1,3,4-trisphosphate 6-kinase activity; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0032957; P:inositol trisphosphate metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1490.220; -; 1.
DR   Gene3D; 3.40.50.11370; -; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   InterPro; IPR008656; Inositol_tetrakis-P_1-kinase.
DR   InterPro; IPR040464; InsP(3)kin_ATP-grasp.
DR   InterPro; IPR041429; ITPK1_N.
DR   PANTHER; PTHR14217; INOSITOL-TETRAKISPHOSPHATE 1-KINASE; 1.
DR   PANTHER; PTHR14217:SF1; INOSITOL-TETRAKISPHOSPHATE 1-KINASE; 1.
DR   Pfam; PF05770; Ins134_P3_kin; 2.
DR   Pfam; PF17927; Ins134_P3_kin_N; 1.
DR   PIRSF; PIRSF038186; ITPK; 2.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR038186-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR038186-2};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          12..78
FT                   /note="Inositol-tetrakisphosphate 1-kinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17927"
FT   DOMAIN          104..180
FT                   /note="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp"
FT                   /evidence="ECO:0000259|Pfam:PF05770"
FT   DOMAIN          182..250
FT                   /note="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp"
FT                   /evidence="ECO:0000259|Pfam:PF05770"
FT   BINDING         215
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038186-2"
FT   BINDING         229
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038186-2"
FT   BINDING         229
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038186-2"
FT   BINDING         231
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038186-2"
SQ   SEQUENCE   291 AA;  32777 MW;  B19B5FA961966BBB CRC64;
     MANNLVIYLF YFQLCRSHGF EFIEIDLNMD LEQQGPFDVV IHKWSDLLAA PSDVSNLIYD
     LQNYFSNHPE TIMLDPIASV CTLVDRSRTY AAVSEYSKEP NSCLHIPNFV TIPENTDKHP
     ILTLLKNAKI RFPIVCKPIV AHGSSLSHTM CIIFNEAGLK DLKSPCVAQQ FINHNAELFK
     CDEKRPVNAM PDDAIISSIV RKLRTSLDLK LFGVDVIIDN ITGLHYVIDV NFFPGYDGFP
     NFFASLFKLF YQVIEGKRGD CFEEINGNHQ NGITRNGISH NGVASQSSGQ K
//