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Protein

DNA ligase

Gene

TRIADDRAFT_57566

Organism
Trichoplax adhaerens (Trichoplax reptans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:TRIADDRAFT_57566Imported
OrganismiTrichoplax adhaerens (Trichoplax reptans)Imported
Taxonomic identifieri10228 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlacozoaTrichoplax
Proteomesi
  • UP000009022 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi10228.TriadP57566

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 93PARP-typeInterPro annotationAdd BLAST89
Domaini460 – 589DNA_LIGASE_A3InterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4437 Eukaryota
COG1793 LUCA
HOGENOMiHOG000007653
InParanoidiB3RZT0
KOiK10776
OMAiDCIYFND
OrthoDBiEOG091G0XBU

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
3.30.1740.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
IPR019406 Znf_C2H2_APLF-like
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF10283 zf-CCHH, 1 hit
PF00645 zf-PARP, 1 hit
SMARTiView protein in SMART
SM01336 zf-PARP, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit

Sequencei

Sequence statusi: Complete.

B3RZT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIEFLAEYD RSGRASCKGC KQKLEKKALR IAKVVENPFG DTGETMKQWH
60 70 80 90 100
HPKCIFNSFI RARPATKIIQ TVADIDGYDD LEDDDQESVS QMITDCLKER
110 120 130 140 150
GNKQSKKKMV QQSIPFAKAY HSSTSNNNNS QDDNSFQLFT SLCDKIGNVG
160 170 180 190 200
SYLAKTKVVA DLLKMGSNGN GYEGDIYLLM KLLLPGIEKR VYNLQSRQLI
210 220 230 240 250
KLFSQIFVCD YDEMLEDLDK GDVAETITDF FANNTAVAPL NRSLLTMQEV
260 270 280 290 300
DDLLDELSNV TKEDMQLKVL KKIARRCTTE DLRYIIRLIK HDLRINAGSR
310 320 330 340 350
HILDALDKNA HAAYQASSDL RDVVDRCLAR KTDRNNDDDD GAPKLKRDLS
360 370 380 390 400
IRASLMTPVR PMLAEACKSI NTAIKKCPKG MFAEIKYDGE RVQIHKNGQQ
410 420 430 440 450
FEYYSRSLKQ VMPHKVKDIK QYLPQACPHG NSIILDSEVL LVDKTGKPLP
460 470 480 490 500
FGTLGVHKKQ NFSDATVCLF IFDCLHFNGK DLMQTRKILE SNVQEIPGRI
510 520 530 540 550
MLSEKKLVQK ENELTGLVSR VIREGLEGLV LKDVESVYEP GKRHWLKIKK
560 570 580 590 600
DYLAEGSMAD SADLVVLGAY YGTGNKGGVM SVFLMGTYDE RSGRWRTVAK
610 620 630 640 650
CGNGHDDKTL DKINKELSVV KISKDFSKVP GWLNVHRSLV PDFIVTDPKT
660 670 680 690 700
APVWEITGAE FSQSTVHTAD GISIRFPRVT RIRDDKDWTN ATNLDRLKTL
710 720 730 740 750
YENSKDASDI ADSLLGVKKE VDDEGECSSS SSPDKTVTRK RKVEELEKEK
760 770 780 790 800
TTIADNKVIS KIPCKYGPNC YRKNGEHLAN YSHNKENGNS SPNACGSQIK
810 820
QDDSSKYMTA SEFWDFYKKS KQS
Length:823
Mass (Da):92,832
Last modified:September 2, 2008 - v1
Checksum:i9D9CAEB850C94A94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985246 Genomic DNA Translation: EDV23892.1
RefSeqiXP_002113418.1, XM_002113382.1

Genome annotation databases

EnsemblMetazoaiTriadT57566; TriadP57566; TriadG57566
GeneIDi6754999
KEGGitad:TRIADDRAFT_57566

Similar proteinsi

Entry informationi

Entry nameiB3RZT0_TRIAD
AccessioniPrimary (citable) accession number: B3RZT0
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health