ID   B3RST7_TRIAD            Unreviewed;       511 AA.
AC   B3RST7;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE            EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN   ORFNames=TRIADDRAFT_54725 {ECO:0000313|EMBL:EDV26583.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV26583.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV26583.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV26583.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC         Evidence={ECO:0000256|RuleBase:RU362059};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; Single-
CC       pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR   EMBL; DS985243; EDV26583.1; -; Genomic_DNA.
DR   RefSeq; XP_002110579.1; XM_002110543.1.
DR   AlphaFoldDB; B3RST7; -.
DR   STRING; 10228.B3RST7; -.
DR   EnsemblMetazoa; TriadT54725; TriadP54725; TriadG54725.
DR   GeneID; 6752311; -.
DR   KEGG; tad:TRIADDRAFT_54725; -.
DR   CTD; 6752311; -.
DR   eggNOG; KOG1192; Eukaryota.
DR   HOGENOM; CLU_012949_3_1_1; -.
DR   InParanoid; B3RST7; -.
DR   OMA; FWDLETP; -.
DR   OrthoDB; 382054at2759; -.
DR   PhylomeDB; B3RST7; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043:SF161; 2-HYDROXYACYLSPHINGOSINE 1-BETA-GALACTOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|RuleBase:RU362059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW   Signal {ECO:0000256|RuleBase:RU362059};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW   Transmembrane {ECO:0000256|RuleBase:RU362059};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362059}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT   CHAIN           25..511
FT                   /note="UDP-glucuronosyltransferase"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT                   /id="PRO_5005122914"
FT   TRANSMEM        479..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
SQ   SEQUENCE   511 AA;  57063 MW;  2B330AC7AC3AAE35 CRC64;
     MGKIWTFTGL CLLITLASLP CTQSLKVGVL PMIGGSHTLS MDLITQQIIK RGHEAVTIIS
     NEPDRLKKLK PSPLALFEID RPATSEDFQS LLISSDPLYP VYGLYDIQTR YCDAILSNKT
     LLQSIQDVDI VVSDGIYFCS ILLPEVLNKP NIQISFSGGI IGFHTFVGQY EPSSYIPLRI
     TLSASGNVEK KMAFAQRAAN FIFGKIFFAL MEYFSVSVVN KLRFKHNIST HLTLHQLRQK
     PSLFLTAVDF SIEYTRPLPP YIQAIGPITP KPASPLPPAF QTIMQNSTSR GVVLVSFGSE
     LQLSDDNLPK MTAALGKLPY TVIWKTRQKI DNIPSNVNVV QWVPQNDILG HRKTIAFITH
     CGSNGLYEGA YHGVPMIGMP GMIEQIGNAE RLLRAGVAIY VDFNNFSEAD IINAVTELVE
     NKRYKDNAVK ISKVIKSRRR SPTDTVVDWI EYVVETDGAH HLKVEGENLW FYEFYNLDVL
     LVVTAIIYII YCVLAFFIKA ICSSKSKAKV D
//