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Protein

DNA ligase

Gene

TRIADDRAFT_50031

Organism
Trichoplax adhaerens (Trichoplax reptans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:TRIADDRAFT_50031Imported
OrganismiTrichoplax adhaerens (Trichoplax reptans)Imported
Taxonomic identifieri10228 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlacozoaTrichoplax
ProteomesiUP000009022: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi10228.JGI50031.

Structurei

3D structure databases

ProteinModelPortaliB3RS92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000007831.
InParanoidiB3RS92.
KOiK10777.
OMAiLQEENQY.
OrthoDBiEOG7BKCT2.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3RS92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKTVADEV PFFDLCTLLE RISQASGKEK KKKIYSDFLS SWRTAHFKLY
60 70 80 90 100
GKSSTEDSFF SAMRLLLPQM DKERLAYGMK ETALAKYYID ILSISKESPA
110 120 130 140 150
AQKLMNYRAP AAAKQDAGDF ASVAFFVLRT RCPEKGTLSI ADVNECLDNI
160 170 180 190 200
AMANSQRKRD DVRNNLRKLL RNTCAMEQKW LIRMIMKELK VGLSENSIFS
210 220 230 240 250
VFHPDASDLF NVSSSLSKVC SDLMDPDVRL NETSIELFVP FRPMLAERCP
260 270 280 290 300
LQQVEKLMNH EMFYIECKAD GDRMQLHKDG NKYMYFSRSS KEYTSSFGAT
310 320 330 340 350
PDEGSFTPFI VNVFSSQVQS AILDGEMVGY DMENDCYVPR GENIDVKAVG
360 370 380 390 400
RTSAIIQQCY MVFDILMLNG KKLANHSLHE RLGYLKQVFT PIPGRIMVVK
410 420 430 440 450
QRQATSKKDV LDSLNEAIDT REEGIIIKNP ISTYKPDQRK GSGWFKIKPE
460 470 480 490 500
YVDSLSDQLD LLIIGGYFGV GRRGGLISHF LLGVAVPPEN PSEHPKVFQS
510 520 530 540 550
FCKVGSGYTI AELKELGEKL KPYWKPMNPK KLPPYFQLMS EKPDLWIEPI
560 570 580 590 600
HSKIVQIKAA EIVPSTDKFK CNCTLRYPRV ELVREDKYWY ECMDLDELDQ
610 620 630 640 650
LKSIAEGRLA YQHADETSET LMFGPSKKRQ KANIRPETVC TIAPQFRTAD
660 670 680 690 700
ISDVSQVFSG KEFCVVSGPK HNPKASVEKR IVENGGTFVQ NPGMETFCVI
710 720 730 740 750
TDRKTIRARN IISQNIYDVV KVDWLLDSLA AGRCLEWQPN QVIHSSPKTA
760 770 780 790 800
EVFAKEYDKY GDSYTKDIDN PVALKAIFDK INNEDDLVST ATQKEICDVE
810 820 830 840 850
MRYFPDESPL GLFRRCRAYF DWYRQVDNDA TRIRDSPLDL IGLNFRYYGG
860 870 880 890 900
TISSILDRHV THIVFDPSDL SRMQKLRKLD KNRKLLRHFV GSEWVTASID
910 920
AASQLSERNY EPLMPRDNSS DSEY
Length:924
Mass (Da):105,469
Last modified:September 2, 2008 - v1
Checksum:i373DF95050126200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985243 Genomic DNA. Translation: EDV27014.1.
RefSeqiXP_002111010.1. XM_002110974.1.

Genome annotation databases

EnsemblMetazoaiTriadT50031; TriadP50031; TriadG50031.
GeneIDi6751687.
KEGGitad:TRIADDRAFT_50031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985243 Genomic DNA. Translation: EDV27014.1.
RefSeqiXP_002111010.1. XM_002110974.1.

3D structure databases

ProteinModelPortaliB3RS92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10228.JGI50031.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiTriadT50031; TriadP50031; TriadG50031.
GeneIDi6751687.
KEGGitad:TRIADDRAFT_50031.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000007831.
InParanoidiB3RS92.
KOiK10777.
OMAiLQEENQY.
OrthoDBiEOG7BKCT2.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Grell-BS-1999Imported.

Entry informationi

Entry nameiB3RS92_TRIAD
AccessioniPrimary (citable) accession number: B3RS92
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: February 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.