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Protein

Dihydroorotate dehydrogenase (quinone), mitochondrial

Gene

TRIADDRAFT_20390

Organism
Trichoplax adhaerens (Trichoplax reptans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per subunit.UniRule annotation

Pathway:iUMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes orotate from (S)-dihydroorotate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydroorotate dehydrogenase (quinone), mitochondrial (TRIADDRAFT_20390)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes orotate from (S)-dihydroorotate (quinone route), the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

Flavoprotein, FMNUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00070; UER00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone), mitochondrialUniRule annotation (EC:1.3.5.2UniRule annotation)
Short name:
DHOdehaseUniRule annotation
Gene namesi
ORF Names:TRIADDRAFT_20390Imported
OrganismiTrichoplax adhaerens (Trichoplax reptans)Imported
Taxonomic identifieri10228 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlacozoaTrichoplax
ProteomesiUP000009022 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi10228.TriadP20390.

Family & Domainsi

Sequence similaritiesi

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0167.
HOGENOMiHOG000225103.
InParanoidiB3RIP0.
KOiK00254.
OMAiAECIDAF.
OrthoDBiEOG7VHSXC.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3RIP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIRNLWKLV GGVAFASVAV SGLIVSQKLL RNDEVFYRTF ALPLLHRLDP
60 70 80 90 100
ETAHRLAIKC ASLGLVPRQS TEDPAELVTT VFKQKFSNPI GLAAGFDKHA
110 120 130 140 150
EAINDLLQMG FGFIEIGSVT PLPQAGNPKP RIFRLIEDRA IINRYGFNSD
160 170 180 190 200
GHEIVAQKLE KWHKNRGREN SSGIVGINLG KNKLSDSAVE DYVKGIQAIG
210 220 230 240 250
KYADYLVINV SSPNTPGLRA LQKKEELQTI ITQISIEREK LKNKPALLIK
260 270 280 290 300
LAPDLTVQDK KDIADVILKE RRNVDGLVIS NTTVRRPNCL TSVSKSEAGG
310 320 330 340 350
LSGPPLREMA TKTIYDMYRL TEGKIPIIGV GGVQSGEDAY EKIRAGASLI
360 370 380 390
QVLTALTYNG PSIIQKIKAD LVTLLRQDGF KSVEEAVGID HRRQ
Length:394
Mass (Da):43,335
Last modified:September 2, 2008 - v1
Checksum:i563C8702B4537C41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985241 Genomic DNA. Translation: EDV29753.1.
RefSeqiXP_002108955.1. XM_002108919.1.

Genome annotation databases

EnsemblMetazoaiTriadT20390; TriadP20390; TriadG20390.
GeneIDi6750169.
KEGGitad:TRIADDRAFT_20390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985241 Genomic DNA. Translation: EDV29753.1.
RefSeqiXP_002108955.1. XM_002108919.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10228.TriadP20390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiTriadT20390; TriadP20390; TriadG20390.
GeneIDi6750169.
KEGGitad:TRIADDRAFT_20390.

Phylogenomic databases

eggNOGiCOG0167.
HOGENOMiHOG000225103.
InParanoidiB3RIP0.
KOiK00254.
OMAiAECIDAF.
OrthoDBiEOG7VHSXC.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00946.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Grell-BS-1999Imported.

Entry informationi

Entry nameiB3RIP0_TRIAD
AccessioniPrimary (citable) accession number: B3RIP0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 22, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.