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Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable L-aspartate dehydrogenase (nadX)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123NAD; via amide nitrogenUniRule annotation1
Binding sitei189NADUniRule annotation1
Active sitei219UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

BioCyciCTAI977880:G1GJV-3716-MONOMER
UniPathwayiUPA00253; UER00456

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
Gene namesi
Name:nadXUniRule annotation
Ordered Locus Names:RALTA_B0572
OrganismiCupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri977880 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000001692 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001400861 – 266Probable L-aspartate dehydrogenaseAdd BLAST266

Interactioni

Protein-protein interaction databases

STRINGi977880.RALTA_B0572

Structurei

3D structure databases

ProteinModelPortaliB3R8S4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Q27 Bacteria
COG1712 LUCA
HOGENOMiHOG000206326
KOiK06989
OMAiMIMSVGA

Family and domain databases

HAMAPiMF_01265 NadX, 1 hit
InterProiView protein in InterPro
IPR005106 Asp/hSer_DH_NAD-bd
IPR002811 Asp_DH
IPR020626 Asp_DH_prok
IPR011182 L-Asp_DH
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01958 DUF108, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF005227 Asp_dh_NAD_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

B3R8S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHVSMVGCG AIGRGVLELL KSDPDVVFDV VIVPEHTMDE ARGAVSALAP
60 70 80 90 100
RARVATHLDD QRPDLLVECA GHHALEEHIV PALERGIPCM VVSVGALSEP
110 120 130 140 150
GMAERLEAAA RRGGTQVQLL SGAIGAIDAL AAARVGGLDE VIYTGRKPAR
160 170 180 190 200
AWTGTPAEQL FDLEALTEAT VIFEGTARDA ARLYPKNANV AATVSLAGLG
210 220 230 240 250
LDRTAVKLLA DPHAVENVHH VEARGAFGGF ELTMRGKPLA ANPKTSALTV
260
FSVVRALGNR AHAVSI
Length:266
Mass (Da):27,799
Last modified:September 2, 2008 - v1
Checksum:iACE91AE7E3C72B96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633750 Genomic DNA Translation: CAQ71192.1
RefSeqiWP_012355417.1, NC_010530.1

Genome annotation databases

EnsemblBacteriaiCAQ71192; CAQ71192; RALTA_B0572
GeneIDi29763879
KEGGicti:RALTA_B0572

Similar proteinsi

Entry informationi

Entry nameiASPD_CUPTR
AccessioniPrimary (citable) accession number: B3R8S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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