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B3R6U7

- PYRF_CUPTR

UniProt

B3R6U7 - PYRF_CUPTR

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, RALTA_A2631
Organism
Cupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCTAI164546:GJNE-2625-MONOMER.
CTAI977880:GLC7-2625-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:RALTA_A2631
OrganismiCupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri164546 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000001692: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000138949Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi164546.RALTA_A2631.

Structurei

3D structure databases

ProteinModelPortaliB3R6U7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiCRTSNAG.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3R6U7-1 [UniParc]FASTAAdd to Basket

« Hide

MTFTEQLAAA WQRNDSLLCV GLDPDPHKLP LSLTGAGGAI FSFCREIVDA    50
TADLVCAFKP QIAYFHSQRA EDQLEQLIHY IHDAHPGIPV ILDAKRGDIG 100
STAEHYALEA FERYKADAVT VSPYMGFDSM QPYLAYPERG VIVLCRTSNP 150
GGSDVQFLQV DGKPLYQLVA EAARERWNTT GQMGLVVGAT FPNEIARVRQ 200
IVGDMPLLIP GIGAQGGDIE ATVKAGRTAD GTGMMINSSR AILYASREKD 250
FAAAARNVAL QTRETINRYR HG 272
Length:272
Mass (Da):29,656
Last modified:September 2, 2008 - v1
Checksum:i3BB941A48960D7B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633749 Genomic DNA. Translation: CAQ70562.1.
RefSeqiYP_002006623.1. NC_010528.1.

Genome annotation databases

EnsemblBacteriaiCAQ70562; CAQ70562; RALTA_A2631.
GeneIDi6453835.
KEGGicti:RALTA_A2631.
PATRICi21531920. VBICupTai42494_2599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633749 Genomic DNA. Translation: CAQ70562.1 .
RefSeqi YP_002006623.1. NC_010528.1.

3D structure databases

ProteinModelPortali B3R6U7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 164546.RALTA_A2631.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ70562 ; CAQ70562 ; RALTA_A2631 .
GeneIDi 6453835.
KEGGi cti:RALTA_A2631.
PATRICi 21531920. VBICupTai42494_2599.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi CRTSNAG.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CTAI164546:GJNE-2625-MONOMER.
CTAI977880:GLC7-2625-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R1 / LMG 19424.

Entry informationi

Entry nameiPYRF_CUPTR
AccessioniPrimary (citable) accession number: B3R6U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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