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B3R6D1

- PUR5_CUPTR

UniProt

B3R6D1 - PUR5_CUPTR

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Cupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTAI164546:GJNE-2546-MONOMER.
CTAI977880:GLC7-2546-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:RALTA_A2552
OrganismiCupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri164546 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000001692: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000193010Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi164546.RALTA_A2552.

Structurei

3D structure databases

ProteinModelPortaliB3R6D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiGEATCEV.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B3R6D1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSASPTAGQA GLSYRDAGVD IDAGDALVDR IKPFAKRTMR EGVMAGIGGF
60 70 80 90 100
GALFELSKKY QEPVLVSGTD GVGTKLKLAF QLNRHDTVGQ DLVAMSVNDI
110 120 130 140 150
LVQGAEPLFF LDYFACGKLD VDTAATVIQG IARGCELAGC ALIGGETAEM
160 170 180 190 200
PSMYPDGEYD LAGFAVGAVE KKKIIDGSTI TPGDVVLGLA SSGAHSNGYS
210 220 230 240 250
LVRKIIEVAK PDLDADFHGQ RLQDAIMAPT RIYVKPLLSL IETLPVKGMA
260 270 280 290 300
HITGGGLTEN VPRVLAQDVT AVLHRDAWTL PPLFQWLQAQ GRVADDEMHR
310 320 330 340 350
VFNCGIGMVV IVAKEDAERA IRHLQAAGEA VWQIGEIRER AEGEAQTIVI
Length:350
Mass (Da):37,270
Last modified:September 2, 2008 - v1
Checksum:i701CBD53002B8963
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633749 Genomic DNA. Translation: CAQ70483.1.
RefSeqiYP_002006544.1. NC_010528.1.

Genome annotation databases

EnsemblBacteriaiCAQ70483; CAQ70483; RALTA_A2552.
GeneIDi6453800.
KEGGicti:RALTA_A2552.
PATRICi21531752. VBICupTai42494_2515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633749 Genomic DNA. Translation: CAQ70483.1 .
RefSeqi YP_002006544.1. NC_010528.1.

3D structure databases

ProteinModelPortali B3R6D1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 164546.RALTA_A2552.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ70483 ; CAQ70483 ; RALTA_A2552 .
GeneIDi 6453800.
KEGGi cti:RALTA_A2552.
PATRICi 21531752. VBICupTai42494_2515.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi GEATCEV.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CTAI164546:GJNE-2546-MONOMER.
CTAI977880:GLC7-2546-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R1 / LMG 19424.

Entry informationi

Entry nameiPUR5_CUPTR
AccessioniPrimary (citable) accession number: B3R6D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3