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B3R5A6 (B3R5A6_CUPTR) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase HAMAP MF_00008
Short name=TS HAMAP MF_00008
Short name=TSase HAMAP MF_00008
EC=2.1.1.45 HAMAP MF_00008
Gene names
Name:thyA HAMAP MF_00008 EMBL CAQ70129.1
Ordered Locus Names:RALTA_A2194
OrganismCupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424)) [Complete proteome] [HAMAP]
Taxonomic identifier164546 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Subunit structure

Homodimer By similarity. HAMAP MF_00008 SAAS SAAS023451

Subcellular location

Cytoplasm By similarity HAMAP MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. RuleBase RU004150

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily. HAMAP MF_00008

Ontologies

Keywords
   Biological processNucleotide biosynthesis HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451
   Cellular componentCytoplasm HAMAP MF_00008
   Molecular functionMethyltransferase SAAS SAAS023451 HAMAP MF_00008 RuleBase RU000500 EMBL CAQ70129.1
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1651 By similarity HAMAP MF_00008

Sequences

Sequence LengthMass (Da)Tools
B3R5A6 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 12A018DAB1EA1D00

FASTA28332,482
        10         20         30         40         50         60 
MPALRAQAPA PPLPSRPAPM KQYLDFMRHV YEHGTDKADR TGTGTRSVFG YQMRFDLREG 

        70         80         90        100        110        120 
FPVVTTKKLH LKSIIYELLW FLQGSTNVRW LQEHGVTIWD EWADEHGELG PVYGSQWRSW 

       130        140        150        160        170        180 
PAPDGRHIDQ ITELVAQIRA NPDSRRLIVS AWNVADIPRM KLPPCHAFFQ FYVADGRLSC 

       190        200        210        220        230        240 
QLYQRSADIF LGVPFNIASY ALLTHMMAQQ TGLEVGDFIW TGGDCHLYNN HFEQVQTQLA 

       250        260        270        280 
REPLALPQLK ILRRPDSIFD YRYEDFELAG YQSHPAIKAP VAV

« Hide

References

[1]"Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and comparative genomics of rhizobia."
Amadou C., Pascal G., Mangenot S., Glew M., Bontemps C., Capela D., Carrere S., Cruveiller S., Dossat C., Lajus A., Marchetti M., Poinsot V., Rouy Z., Servin B., Saad M., Schenowitz C., Barbe V., Batut J., Medigue C., Masson-Boivin C.
Genome Res. 18:1472-1483(2008) [PubMed: 18490699] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU633749 Genomic DNA. Translation: CAQ70129.1.
RefSeqYP_002006192.1. NC_010528.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB3R5A6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6453590.
GenomeReviewsGene locus RALTA_A2194 in contig CU633749_GR.
KEGGcti:RALTA_A2194.
PATRIC21531024. VBICupTai42494_2155.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG588098.
OMADIPRMKL.
ProtClustDBPRK01827.

Family and domain databases

HAMAPMF_00008. Thymidy_synth_bact.
[Tree]
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
KOK00560.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. Thym_sym. 2 hits.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3R5A6_CUPTR
AccessionPrimary (citable) accession number: B3R5A6
Entry history
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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