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B3R3W3

- PNP_CUPTR

UniProt

B3R3W3 - PNP_CUPTR

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, RALTA_A1030
Organism
Cupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881Magnesium By similarity
Metal bindingi494 – 4941Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCTAI164546:GJNE-1016-MONOMER.
CTAI977880:GLC7-1016-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:RALTA_A1030
OrganismiCupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri164546 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000001692: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_1000147911Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi164546.RALTA_A1030.

Structurei

3D structure databases

ProteinModelPortaliB3R3W3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KH
Add
BLAST
Domaini624 – 69269S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3R3W3-1 [UniParc]FASTAAdd to Basket

« Hide

MSMFNKVVKE FQWGQHKVRM ETGEIARQAG GAVLVDVEDT VVLATVVAAK    50
SPKPGQDFFP LTVDYIEKTY AAGKIPGGFF KREGRPSENE TLTSRLIDRP 100
LRPLFPEGFY NDVQVVVHVV SLNPEVPADI PALIGASAAL AVSGIPFNGP 150
VGAARVGYKD GQYLLNPTRS QIATSDLDLV VAGTERAVLM VESEANQLSE 200
DVMLGAVVYG HEQMQTAINA IHELVREGGK PEWDWAPAAK NEPLIAKVTE 250
VALPLLQEAY QLRQKSARSQ KLKEVSANVA AALAEAGVEA DKVEVGNIMF 300
DLEAKIVRGQ ILNGEPRIDG RDTRTVRPIE IRSSVLPRAH GSALFTRGET 350
QALVVATLGT KSDEQIIDAL AGEYRDRFML HYNMPPFATG ETGRVGSPKR 400
REIGHGRLAK RALIPVLPKE DEFAYTIRLV SEITESNGSS SMASVCGGCL 450
ALMDAGVPVK AHVAGVAMGL ILEGNKFAVL TDILGDEDHL GDMDFKVAGT 500
DNGITALQMD IKVQGITKEI MQVALAQAKE GRLHILSNMQ EAMGHARTEL 550
SAHAPRMITM KIHPDKIREV IGKGGSTIQA LTKETGTTID IQEDGTITIA 600
STSTEGMAEA KRRIEGITAE AEVGKIYAGT VLKLLDFGAI VNILPGKDGL 650
LHISEIVNER VKDIKDWLKE GQQVRVKLIQ ADEKGRLRLS LKAALAEEGG 700
SISPINAGES AAPAAPAGGS EQQ 723
Length:723
Mass (Da):77,627
Last modified:September 2, 2008 - v1
Checksum:i32A9082837842113
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633749 Genomic DNA. Translation: CAQ68995.1.
RefSeqiYP_002005062.1. NC_010528.1.

Genome annotation databases

EnsemblBacteriaiCAQ68995; CAQ68995; RALTA_A1030.
GeneIDi6452858.
KEGGicti:RALTA_A1030.
PATRICi21528636. VBICupTai42494_0996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633749 Genomic DNA. Translation: CAQ68995.1 .
RefSeqi YP_002005062.1. NC_010528.1.

3D structure databases

ProteinModelPortali B3R3W3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 164546.RALTA_A1030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ68995 ; CAQ68995 ; RALTA_A1030 .
GeneIDi 6452858.
KEGGi cti:RALTA_A1030.
PATRICi 21528636. VBICupTai42494_0996.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CTAI164546:GJNE-1016-MONOMER.
CTAI977880:GLC7-1016-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R1 / LMG 19424.

Entry informationi

Entry nameiPNP_CUPTR
AccessioniPrimary (citable) accession number: B3R3W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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