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Protein

Adenine deaminase

Gene

RALTA_A0998

Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.UniRule annotation

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Zinc; catalyticUniRule annotation
Metal bindingi22 – 221Zinc; catalyticUniRule annotation
Metal bindingi200 – 2001Zinc; catalyticUniRule annotation
Active sitei203 – 2031Proton donorUniRule annotation
Sitei224 – 2241Important for catalytic activityUniRule annotation
Metal bindingi281 – 2811Zinc; catalyticUniRule annotation
Binding sitei282 – 2821SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciCTAI164546:GJNE-984-MONOMER.
CTAI977880:GLC7-984-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
ADEUniRule annotation
Alternative name(s):
Adenine aminohydrolaseUniRule annotation
Short name:
AAHUniRule annotation
Gene namesi
Ordered Locus Names:RALTA_A0998
OrganismiCupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri977880 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000001692 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Adenine deaminasePRO_1000128838Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi977880.RALTA_A0998.

Structurei

3D structure databases

ProteinModelPortaliB3R3T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218813.
KOiK01488.
OMAiDHGVRAI.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

B3R3T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDAALAEQ IRRTPKAELH VHIEGTLEPE LIFRLAQRNQ VALPYPSVDA
60 70 80 90 100
LRAAYAFTDL QSFLDIYYAG ASVLLTEEDF FDMTMDYVKR AVADNVRHAE
110 120 130 140 150
IFFDPQTHTA RGVPIGVVID GIADALAQAR TEYDFSSSLI LCFLRHLSEE
160 170 180 190 200
DAFATLEAAL PYRDRFVGVG LDSSEKGNPP EKFARVFARA RELGLHLVAH
210 220 230 240 250
AGEEGPAQYV ADALDILKAE RIDHGVRAID DAALVERLAR ERVALTVCPL
260 270 280 290 300
SNVKLKVYPD LRDHPLKRML DAGVAITLHS DDPAYFGGYM NANWEATFDA
310 320 330 340 350
LPLDAADAHK LARNSFEAAF LPAMQKAEFL AEVDHFWSAP PKSPPATAPA

A
Length:351
Mass (Da):38,700
Last modified:September 2, 2008 - v1
Checksum:i594A3F8827C0B09E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633749 Genomic DNA. Translation: CAQ68963.1.
RefSeqiWP_012352296.1. NC_010528.1.

Genome annotation databases

EnsemblBacteriaiCAQ68963; CAQ68963; RALTA_A0998.
KEGGicti:RALTA_A0998.
PATRICi21528568. VBICupTai42494_0962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633749 Genomic DNA. Translation: CAQ68963.1.
RefSeqiWP_012352296.1. NC_010528.1.

3D structure databases

ProteinModelPortaliB3R3T1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi977880.RALTA_A0998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ68963; CAQ68963; RALTA_A0998.
KEGGicti:RALTA_A0998.
PATRICi21528568. VBICupTai42494_0962.

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218813.
KOiK01488.
OMAiDHGVRAI.

Enzyme and pathway databases

BioCyciCTAI164546:GJNE-984-MONOMER.
CTAI977880:GLC7-984-MONOMER.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADE_CUPTR
AccessioniPrimary (citable) accession number: B3R3T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.