Reviewed, UniProtKB/Swiss-Prot B3R3T1 (ADD_CUPTR)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	RALTA_A0998

Organism

Cupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424)) [Complete proteome] [HAMAP]

Taxonomic identifier

164546 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Adenosine deaminase HAMAP MF_00540		PRO_1000128838
Sites
	Active site	200	1	Potential
	Active site	248	1	Potential
	Active site	281	1	Potential
	Active site	282	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	B3R3T1-1 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 594A3F8827C0B09E	FASTA	351	38,700
	10 20 30 40 50 60 MTIDAALAEQ IRRTPKAELH VHIEGTLEPE LIFRLAQRNQ VALPYPSVDA LRAAYAFTDL 70 80 90 100 110 120 QSFLDIYYAG ASVLLTEEDF FDMTMDYVKR AVADNVRHAE IFFDPQTHTA RGVPIGVVID 130 140 150 160 170 180 GIADALAQAR TEYDFSSSLI LCFLRHLSEE DAFATLEAAL PYRDRFVGVG LDSSEKGNPP 190 200 210 220 230 240 EKFARVFARA RELGLHLVAH AGEEGPAQYV ADALDILKAE RIDHGVRAID DAALVERLAR 250 260 270 280 290 300 ERVALTVCPL SNVKLKVYPD LRDHPLKRML DAGVAITLHS DDPAYFGGYM NANWEATFDA 310 320 330 340 350 LPLDAADAHK LARNSFEAAF LPAMQKAEFL AEVDHFWSAP PKSPPATAPA A

References

[1]

"Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and comparative genomics of rhizobia." Amadou C., Pascal G., Mangenot S., Glew M., Bontemps C., Capela D., Carrere S., Cruveiller S., Dossat C., Lajus A., Marchetti M., Poinsot V., Rouy Z., Servin B., Saad M., Schenowitz C., Barbe V., Batut J., Medigue C., Masson-Boivin C. Genome Res. 18:1472-1483(2008) [PubMed: 18490699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU633749 Genomic DNA. Translation: CAQ68963.1.
RefSeq	YP_002005030.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6454570.
GenomeReviews	Gene locus RALTA_A0998 in contig CU633749_GR.
KEGG	cti:RALTA_A0998.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LAQNSLD.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_CUPTR

Accession

Primary (citable) accession number: B3R3T1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 2, 2008
Last modified:	November 3, 2009
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)