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B3R362 (B3R362_CUPTR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length892 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
B3R362 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 61D165C3C7547E08

FASTA89299,026
        10         20         30         40         50         60 
MDPFAKETLP VSLEEEMRRS YLDYAMSVIV GRALPDVRDG LKPVHRRVLY AMHELNNDWN 

        70         80         90        100        110        120 
RAYKKSARIV GDVIGKYHPH GDTAVYDTIV RMAQDFSLRY MLVDGQGNFG SVDGDNAAAM 

       130        140        150        160        170        180 
RYTEIRLSKI AHEMLHDIDK ETVDFDSNYD GSEKEPSILP ARIPNLLING SSGIAVGMAT 

       190        200        210        220        230        240 
NIPPHNLNEI VDGCLHLLRN PQATVDELIE LIPAPDFPTA GIIYGIQGVR EGYRTGRGRV 

       250        260        270        280        290        300 
VMRAKTHFED IDRGQRQAII VDELPYQVNK RTLLERIAEL VTEKKIEGIS DIRDESDKSG 

       310        320        330        340        350        360 
MRVVIELKRN EVPEVVLNNL YKNTQLQDTF GMNMVALVDR QPRLLNLRQM LEYFLAHRRE 

       370        380        390        400        410        420 
VVTRRTVFEL RKARERGHVL EGLAVALANI DEFIAIIKAA PTPPIAKQEL MSKAWDSALV 

       430        440        450        460        470        480 
REMLARAEGE TPGGRASYRP DGLPAVFGMQ PDGLYRLSDG QAQEILQMRL QRLTGLEQDK 

       490        500        510        520        530        540 
IVQEYRDIMA EIADLLDILA RPERITTIII DELTAIRAEF GDERRSQIEL NATELDTEDL 

       550        560        570        580        590        600 
ITPQDMVVTL SHSGYMKSQP ISEYRAQKRG GRGKQAAATK EDDWIDTLFV ANTHDYILCF 

       610        620        630        640        650        660 
SNRGRLYWLK VYEVPQGSRN SRGRPIVNMF PLSEGEKINV ILPVRQFDAE HFIFMATARG 

       670        680        690        700        710        720 
TVKKTALTEF SNPRKAGIIA VDLDEGDYLI GAAVTDGQHD VMLFSDAGKA VRFDENDVRP 

       730        740        750        760        770        780 
MGRQARGVRG MNLEEGQAVI AMLVAPAETA EEAADAGVRG SVLTATENGY GKRTPIAEYT 

       790        800        810        820        830        840 
RHGRGTKGMI AIQTSERNGR VVAAALVSPE DEIMLITTGG VLIRTRVAEI REMGRATQGV 

       850        860        870        880        890 
TLINVDEGTK LSGLQRIVES DADNGGNGEE PEEADGTEGA EGAAGADADA KP

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References

[1]"Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and comparative genomics of rhizobia."
Amadou C., Pascal G., Mangenot S., Glew M., Bontemps C., Capela D., Carrere S., Cruveiller S., Dossat C., Lajus A., Marchetti M., Poinsot V., Rouy Z., Servin B., Saad M., Schenowitz C., Barbe V., Batut J., Medigue C., Masson-Boivin C.
Genome Res. 18:1472-1483(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R1 / LMG 19424.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU633749 Genomic DNA. Translation: CAQ68742.1.
RefSeqYP_002004811.1. NC_010528.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING164546.RALTA_A0770.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAQ68742; CAQ68742; RALTA_A0770.
GeneID6452699.
KEGGcti:RALTA_A0770.
PATRIC21528166. VBICupTai42494_0765.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycCTAI164546:GJNE-758-MONOMER.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB3R362_CUPTR
AccessionPrimary (citable) accession number: B3R362
Entry history
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info