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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei246ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTAI977880:G1GJV-1900-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:RALTA_A1946
OrganismiCupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri977880 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000001692 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000900681 – 466Glutamate--tRNA ligaseAdd BLAST466

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi977880.RALTA_A1946

Structurei

3D structure databases

ProteinModelPortaliB3R1N9
SMRiB3R1N9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi243 – 247"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.8.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B3R1N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQRVRTRFA PSPTGFIHLG NIRSALYPWA FARRMQGDFI LRIEDTDVER
60 70 80 90 100
SSQEAVDVIL ESMAWLELDI DEGPFYQMQR MDRYREVVAQ MVEAGLAYRC
110 120 130 140 150
YMSTAELDAL REAQRERGEK PRYNGFWRPE PGKVLPEPPA GVDPVIRFKN
160 170 180 190 200
PIGGSVVWDD AVKGRIEISN DELDDLVIAR PDGTPTYNFC VVVDDLDMRI
210 220 230 240 250
THVIRGDDHV NNTPRQINII RALGGTPPVY AHLPTVLNEQ GEKMSKRHGA
260 270 280 290 300
MSVTGYRDEG YLPEAVLNYL ARLGWAHGDA EIFSREQFVE WFDLEHLGKS
310 320 330 340 350
PAQYNPEKLA WLNNHYIKVG DNQRLATLTQ PFIEALGGKV EGADLVGVIA
360 370 380 390 400
LVKDRANTLK EVAQAALLFY RGEPQADAAL KAEHLTPEIQ PALAALSARL
410 420 430 440 450
GALPSWTREE ISATFKAVLA EFGLKMPKLA MPVRLLVAGQ LQTPSIDAVL
460
ELFGRDTVLR RLAAAA
Length:466
Mass (Da):52,110
Last modified:September 2, 2008 - v1
Checksum:iDF24D56EA9A6D231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633749 Genomic DNA Translation: CAQ69887.1
RefSeqiWP_012353198.1, NC_010528.1

Genome annotation databases

EnsemblBacteriaiCAQ69887; CAQ69887; RALTA_A1946
GeneIDi29761084
KEGGicti:RALTA_A1946

Similar proteinsi

Entry informationi

Entry nameiSYE_CUPTR
AccessioniPrimary (citable) accession number: B3R1N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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