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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107Proton acceptorUniRule annotation1
Binding sitei125SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BioCyciCTAI977880:G1GJV-1837-MONOMER
UniPathwayiUPA00115; UER00412

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:RALTA_A1890
OrganismiCupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri977880 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000001692 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000976591 – 228Ribose-5-phosphate isomerase AAdd BLAST228

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi977880.RALTA_A1890

Structurei

3D structure databases

ProteinModelPortaliB3R1I3
SMRiB3R1I3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 35Substrate bindingUniRule annotation4
Regioni85 – 88Substrate bindingUniRule annotation4
Regioni98 – 101Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66 Bacteria
COG0120 LUCA
HOGENOMiHOG000276368
KOiK01807
OMAiVAPMAYV

Family and domain databases

CDDicd01398 RPI_A, 1 hit
HAMAPiMF_00170 Rib_5P_isom_A, 1 hit
InterProiView protein in InterPro
IPR037171 NagB/RpiA_transferase-like
IPR004788 Ribose5P_isomerase_typA
IPR020672 Ribose5P_isomerase_typA_subgr
PfamiView protein in Pfam
PF06026 Rib_5-P_isom_A, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00021 rpiA, 1 hit

Sequencei

Sequence statusi: Complete.

B3R1I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDELKALV AQAAADYVKQ EVPEGAVLGV GTGSTANLFI DAVAAFKDRF
60 70 80 90 100
AGAVSSSEAS TRRLQQHGFK VLDLNEVDEI PVYVDGADEI DASGAMVKGG
110 120 130 140 150
GGALTREKIV ASVARRFVCI ADGSKLVQTM GAFPLPVEVV PMARAAVARK
160 170 180 190 200
LQALGGQPRL RMTKEGGIYK TDNGNVILDV AGLKIDDPRG LEQTINQVPG
210 220
VVTVGLFALR GADVLLLGTG DGVQRTDY
Length:228
Mass (Da):23,853
Last modified:September 2, 2008 - v1
Checksum:i29E1D9250E0FDC6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633749 Genomic DNA Translation: CAQ69831.1
RefSeqiWP_012353146.1, NC_010528.1

Genome annotation databases

EnsemblBacteriaiCAQ69831; CAQ69831; RALTA_A1890
GeneIDi29763339
KEGGicti:RALTA_A1890

Similar proteinsi

Entry informationi

Entry nameiRPIA_CUPTR
AccessioniPrimary (citable) accession number: B3R1I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health