Reviewed, UniProtKB/Swiss-Prot B3R1A0 (UXUA_CUPTR)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	RALTA_A1563

Organism

Cupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424)) [Complete proteome] [HAMAP]

Taxonomic identifier

164546 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Mannonate dehydratase HAMAP MF_00106		PRO_1000094214

Sequences

	Sequence		Length	Mass (Da)
	B3R1A0-1 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 36C0CCA193D86B63	FASTA	346	38,515
	10 20 30 40 50 60 MKMSFRWFGP TDPIPLEYIR QIPGMTHIVS AIYDEPVGEV WPLDKIQALK STIEAAGLQF 70 80 90 100 110 120 KVVESVPVHE DIKLGKPTRE RLIANYQQTI RNLAAAGIEV ICYNFMPVFD WTRTELAKKL 130 140 150 160 170 180 DDGSTCLAFS TREVEQIDVS QGIALPGWDS SYAHAELQSL LAEYRGIDEG RLWEHLEHFL 190 200 210 220 230 240 RAIIPVAQEC GIKMAIHPDD PPRPIFGLPR IVKNRDDLAR ILAIVDTPAN GLTLCSGSLG 250 260 270 280 290 300 AGPQNNVEAL VREFGGMGRI HFAHIRNVKI TPEGDFEETA HLSSCGSLDI AAIVKAYHDV 310 320 330 340 GFQGYYRPDH GRMIWGETGK PGYGLYDRAL GAVYINGMWE AMEKTA

References

[1]

"Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and comparative genomics of rhizobia." Amadou C., Pascal G., Mangenot S., Glew M., Bontemps C., Capela D., Carrere S., Cruveiller S., Dossat C., Lajus A., Marchetti M., Poinsot V., Rouy Z., Servin B., Saad M., Schenowitz C., Barbe V., Batut J., Medigue C., Masson-Boivin C. Genome Res. 18:1472-1483(2008) [PubMed: 18490699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU633749 Genomic DNA. Translation: CAQ69509.1.
RefSeq	YP_002005576.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6453219.
GenomeReviews	Gene locus RALTA_A1563 in contig CU633749_GR.
KEGG	cti:RALTA_A1563.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG585927.
OMA	DIKLGKP.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_CUPTR

Accession

Primary (citable) accession number: B3R1A0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 2, 2008
Last modified:	February 9, 2010
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)