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B3QZX0

- TYSY_PHYMT

UniProt

B3QZX0 - TYSY_PHYMT

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Protein
Thymidylate synthase
Gene
thyA, ATP_00320
Organism
Phytoplasma mali (strain AT)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701 By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciPMAL37692:GC0T-347-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:thyA
Ordered Locus Names:ATP_00320
OrganismiPhytoplasma mali (strain AT)
Taxonomic identifieri482235 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus Phytoplasma16SrX (Apple proliferation group)
ProteomesiUP000002020: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Thymidylate synthaseUniRule annotation
PRO_1000197255Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi37692.ATP_00320.

Structurei

3D structure databases

ProteinModelPortaliB3QZX0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiRYIMENG.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QZX0-1 [UniParc]FASTAAdd to Basket

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MQAYLNLCRD ILNYGKKKID RTKTGTRSIF GYQMRFNLEK GFPLLTTKKM    50
NFKAIIHELL WFIKGDTNIR YLVQNNVNIW NEWPYQKYCN SNFFQNLTLQ 100
EFIDKIIIDE KFAKIHGDLG PIYGHQWRNF QGIDQLTDLI SEIKKNPHSR 150
RLILTAWDPT VIKDMLLPPC HVMIQCYVEK NKISMQLYQR SGDVFLGIPF 200
NIASYSLLLI IIAQCTGLKP FEFIHTIGDA HIYNNHIEQI QKQIKRIPKK 250
LPIMTLNPHI IDINQFTFND FNLEKYESYG ILKGVVAV 288
Length:288
Mass (Da):33,877
Last modified:September 2, 2008 - v1
Checksum:i249B72FE6CE885B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU469464 Genomic DNA. Translation: CAP18507.1.
RefSeqiYP_002004353.1. NC_011047.1.

Genome annotation databases

EnsemblBacteriaiCAP18507; CAP18507; ATP_00320.
GeneIDi6450519.
KEGGipml:ATP_00320.
PATRICi31994891. VBICanPhy52977_0332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU469464 Genomic DNA. Translation: CAP18507.1 .
RefSeqi YP_002004353.1. NC_011047.1.

3D structure databases

ProteinModelPortali B3QZX0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 37692.ATP_00320.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP18507 ; CAP18507 ; ATP_00320 .
GeneIDi 6450519.
KEGGi pml:ATP_00320.
PATRICi 31994891. VBICanPhy52977_0332.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi RYIMENG.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci PMAL37692:GC0T-347-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The linear chromosome of the plant-pathogenic mycoplasma 'Candidatus Phytoplasma mali'."
    Kube M., Schneider B., Kuhl H., Dandekar T., Heitmann K., Migdoll A.M., Reinhardt R., Seemueller E.
    BMC Genomics 9:306-306(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AT.

Entry informationi

Entry nameiTYSY_PHYMT
AccessioniPrimary (citable) accession number: B3QZX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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