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B3QZX0 (TYSY_PHYMT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate synthase

Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:thyA
Ordered Locus Names:ATP_00320
OrganismPhytoplasma mali (strain AT) [Complete proteome] [HAMAP]
Taxonomic identifier482235 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus Phytoplasma16SrX (Apple proliferation group)

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP-Rule MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00008

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Cellular componentCytoplasm
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Thymidylate synthase HAMAP-Rule MF_00008
PRO_1000197255

Sites

Active site1701 By similarity

Sequences

Sequence LengthMass (Da)Tools
B3QZX0 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 249B72FE6CE885B1

FASTA28833,877
        10         20         30         40         50         60 
MQAYLNLCRD ILNYGKKKID RTKTGTRSIF GYQMRFNLEK GFPLLTTKKM NFKAIIHELL 

        70         80         90        100        110        120 
WFIKGDTNIR YLVQNNVNIW NEWPYQKYCN SNFFQNLTLQ EFIDKIIIDE KFAKIHGDLG 

       130        140        150        160        170        180 
PIYGHQWRNF QGIDQLTDLI SEIKKNPHSR RLILTAWDPT VIKDMLLPPC HVMIQCYVEK 

       190        200        210        220        230        240 
NKISMQLYQR SGDVFLGIPF NIASYSLLLI IIAQCTGLKP FEFIHTIGDA HIYNNHIEQI 

       250        260        270        280 
QKQIKRIPKK LPIMTLNPHI IDINQFTFND FNLEKYESYG ILKGVVAV 

« Hide

References

[1]"The linear chromosome of the plant-pathogenic mycoplasma 'Candidatus Phytoplasma mali'."
Kube M., Schneider B., Kuhl H., Dandekar T., Heitmann K., Migdoll A.M., Reinhardt R., Seemueller E.
BMC Genomics 9:306-306(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU469464 Genomic DNA. Translation: CAP18507.1.
RefSeqYP_002004353.1. NC_011047.1.

3D structure databases

ProteinModelPortalB3QZX0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING37692.ATP_00320.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP18507; CAP18507; ATP_00320.
GeneID6450519.
KEGGpml:ATP_00320.
PATRIC31994891. VBICanPhy52977_0332.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0207.
HOGENOMHOG000257899.
KOK00560.
OMANLGPVYG.
OrthoDBEOG6K6V53.
ProtClustDBPRK01827.

Enzyme and pathway databases

BioCycPMAL37692:GC0T-347-MONOMER.
UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. SSF55831. 1 hit.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTYSY_PHYMT
AccessionPrimary (citable) accession number: B3QZX0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 2, 2008
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways