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B3QZX0

- TYSY_PHYMT

UniProt

B3QZX0 - TYSY_PHYMT

Protein

Thymidylate synthase

Gene

thyA

Organism
Phytoplasma mali (strain AT)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei170 – 1701UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciPMAL37692:GC0T-347-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:ATP_00320
    OrganismiPhytoplasma mali (strain AT)
    Taxonomic identifieri482235 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus Phytoplasma16SrX (Apple proliferation group)
    ProteomesiUP000002020: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Thymidylate synthasePRO_1000197255Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi37692.ATP_00320.

    Structurei

    3D structure databases

    ProteinModelPortaliB3QZX0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257899.
    KOiK00560.
    OMAiRYIMENG.
    OrthoDBiEOG6K6V53.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3QZX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQAYLNLCRD ILNYGKKKID RTKTGTRSIF GYQMRFNLEK GFPLLTTKKM    50
    NFKAIIHELL WFIKGDTNIR YLVQNNVNIW NEWPYQKYCN SNFFQNLTLQ 100
    EFIDKIIIDE KFAKIHGDLG PIYGHQWRNF QGIDQLTDLI SEIKKNPHSR 150
    RLILTAWDPT VIKDMLLPPC HVMIQCYVEK NKISMQLYQR SGDVFLGIPF 200
    NIASYSLLLI IIAQCTGLKP FEFIHTIGDA HIYNNHIEQI QKQIKRIPKK 250
    LPIMTLNPHI IDINQFTFND FNLEKYESYG ILKGVVAV 288
    Length:288
    Mass (Da):33,877
    Last modified:September 2, 2008 - v1
    Checksum:i249B72FE6CE885B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU469464 Genomic DNA. Translation: CAP18507.1.
    RefSeqiYP_002004353.1. NC_011047.1.

    Genome annotation databases

    EnsemblBacteriaiCAP18507; CAP18507; ATP_00320.
    GeneIDi6450519.
    KEGGipml:ATP_00320.
    PATRICi31994891. VBICanPhy52977_0332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU469464 Genomic DNA. Translation: CAP18507.1 .
    RefSeqi YP_002004353.1. NC_011047.1.

    3D structure databases

    ProteinModelPortali B3QZX0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 37692.ATP_00320.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP18507 ; CAP18507 ; ATP_00320 .
    GeneIDi 6450519.
    KEGGi pml:ATP_00320.
    PATRICi 31994891. VBICanPhy52977_0332.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257899.
    KOi K00560.
    OMAi RYIMENG.
    OrthoDBi EOG6K6V53.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci PMAL37692:GC0T-347-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The linear chromosome of the plant-pathogenic mycoplasma 'Candidatus Phytoplasma mali'."
      Kube M., Schneider B., Kuhl H., Dandekar T., Heitmann K., Migdoll A.M., Reinhardt R., Seemueller E.
      BMC Genomics 9:306-306(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AT.

    Entry informationi

    Entry nameiTYSY_PHYMT
    AccessioniPrimary (citable) accession number: B3QZX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3