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Protein

Acetate kinase

Gene

ackA

Organism
Phytoplasma mali (strain AT)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Active sitei145Proton donor/acceptorUniRule annotation1
Sitei177Transition state stabilizerUniRule annotation1
Sitei236Transition state stabilizerUniRule annotation1
Metal bindingi378MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 207ATPUniRule annotation5
Nucleotide bindingi278 – 280ATPUniRule annotation3
Nucleotide bindingi326 – 330ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:ATP_00319
OrganismiPhytoplasma mali (strain AT)
Taxonomic identifieri482235 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus Phytoplasma16SrX (Apple proliferation group)
Proteomesi
  • UP000002020 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001168061 – 391Acetate kinaseAdd BLAST391

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi37692.ATP_00319.

Structurei

3D structure databases

ProteinModelPortaliB3QZW9.
SMRiB3QZW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288398.
KOiK00925.
OMAiWKALTGT.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QZW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIISVNAGS SSLKFKLFDM PKEELIFSGL IEKIGDQKSI FSLSYGNTKK
60 70 80 90 100
ETIMPVLNHQ QAVKLLLDSL QINKIIDNLE EIKGVGHRIV QGGELFKDSV
110 120 130 140 150
VLTEENILKI ESLNDLAPLH NYANVLGIKA FEKNIPNIFQ VGVFDTTFHQ
160 170 180 190 200
TIKQENFSYA IPYEWYQKYK IRKYGFHGIS YKYVSNRTSE ILANKDSKII
210 220 230 240 250
VCHAGNGVSL CAIEGNNSVD TSMGFTPLEG VPMGTRSGNI DPTIIEFISY
260 270 280 290 300
KENKSIKEIM NILNKKSGFL GVSGVSNDAR DIEISLQNGN KRSLLAHDVQ
310 320 330 340 350
IKRICDYIGS YYFLLKGIDA LVFTAGMGEN SSLFRKKIIQ RLSFLGVFLD
360 370 380 390
DEFNNSKGER IISTSNSFFK VLVIPTNEEI EIVREVCKIK N
Length:391
Mass (Da):43,938
Last modified:September 2, 2008 - v1
Checksum:i498750319D7036F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU469464 Genomic DNA. Translation: CAP18506.1.

Genome annotation databases

EnsemblBacteriaiCAP18506; CAP18506; ATP_00319.
KEGGipml:ATP_00319.

Similar proteinsi

Entry informationi

Entry nameiACKA_PHYMT
AccessioniPrimary (citable) accession number: B3QZW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 2, 2008
Last modified: July 5, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families