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B3QZG1

- PNP_PHYMT

UniProt

B3QZG1 - PNP_PHYMT

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Phytoplasma mali (strain AT)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi513 – 5131MagnesiumUniRule annotation
    Metal bindingi519 – 5191MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciPMAL37692:GC0T-415-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:ATP_00381
    OrganismiPhytoplasma mali (strain AT)
    Taxonomic identifieri482235 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus Phytoplasma16SrX (Apple proliferation group)
    ProteomesiUP000002020: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 728728Polyribonucleotide nucleotidyltransferasePRO_0000381910Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi37692.ATP_00381.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini580 – 64061KHUniRule annotationAdd
    BLAST
    Domaini650 – 72475S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiGTENTIC.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3QZG1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLNTKNNNK KVFEIIFENN VLRIEIGEIS RQANGSVMLF YKDTVILSVA    50
    VCGDKKNSLN FLPLTVNYQE KLYAAGKIPG GFLRREGKPS DQEILCSRLI 100
    DRTIRPLFSK NFKNEVQLIN MVLSSDPDGN NENIALLGSS LALLISDIPF 150
    FEPVSSVCVG KIGDNLIINP TLSQRENSSF FLILAGTKDS LNMVEMSSKE 200
    ISENNFLESI KFGHEIIKKL CLFQTEIANQ IGKTKIKIPL HNVNNLLEVE 250
    IKDKYFSEIE MILKNKCNVN NVKKSDILKK LKENVLENYK EKFLNNKKDN 300
    FNLLDLENQK LYLNEVEIIF DFLVRTIIRE TILKENIRPD GRNSSEIRSI 350
    TSRIDILPRT HGSALFTRGG TQSLAIVTLG TLRESKIIDD LSDEVDKRFM 400
    LHYNFPAFAV GSVGRYLAPS RREIGHGMLA EKALECVLPS ENDFPYSIRV 450
    VSEILDSNGS SSQATICASS MALMSAGVPL KSLVAGVAMG LIVDDIDKIN 500
    HYTILSDIEG LEDYQGDIDF KIAGTKVGIT ALQLDIKIKG ITLEIFEKVL 550
    EQAKKDRIKI LNEMEKVINK SRNEVSKYAP KVKMILIKPE KIRDIIGSGG 600
    KIINQIIEKH DNVKIDIMQD GKIYIMHQNM EIVDLTVTYI QNFLKKIKVE 650
    NVYEVKILRF VKDKMDKTFG AIAEIFPGIE GFIHISKLEN YKVDKVEDVL 700
    KIGQIILVKC IKINERGQID LSKKDVFK 728
    Length:728
    Mass (Da):82,279
    Last modified:September 2, 2008 - v1
    Checksum:i84D02E226ACDBDE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU469464 Genomic DNA. Translation: CAP18568.1.
    RefSeqiYP_002004412.1. NC_011047.1.

    Genome annotation databases

    EnsemblBacteriaiCAP18568; CAP18568; ATP_00381.
    GeneIDi6450674.
    KEGGipml:ATP_00381.
    PATRICi31995025. VBICanPhy52977_0393.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU469464 Genomic DNA. Translation: CAP18568.1 .
    RefSeqi YP_002004412.1. NC_011047.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 37692.ATP_00381.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP18568 ; CAP18568 ; ATP_00381 .
    GeneIDi 6450674.
    KEGGi pml:ATP_00381.
    PATRICi 31995025. VBICanPhy52977_0393.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi GTENTIC.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci PMAL37692:GC0T-415-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The linear chromosome of the plant-pathogenic mycoplasma 'Candidatus Phytoplasma mali'."
      Kube M., Schneider B., Kuhl H., Dandekar T., Heitmann K., Migdoll A.M., Reinhardt R., Seemueller E.
      BMC Genomics 9:306-306(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AT.

    Entry informationi

    Entry nameiPNP_PHYMT
    AccessioniPrimary (citable) accession number: B3QZG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3