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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei262ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTHA517418:G1GC9-2809-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Ctha_2685
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
Proteomesi
  • UP000001208 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000900641 – 503Glutamate--tRNA ligaseAdd BLAST503

Proteomic databases

PRIDEiB3QYR1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi517418.Ctha_2685

Structurei

3D structure databases

ProteinModelPortaliB3QYR1
SMRiB3QYR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 22"HIGH" regionUniRule annotationAdd BLAST11
Motifi259 – 263"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B3QYR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQTIRTRF APSPTGYLHV GGLRTALYNF LFAKKNGGQF LLRLEDTDRA
60 70 80 90 100
RLVEGAVENL LSSLEWAGII PDESPKHGGD FGPYVQSERL DIYKQYVQQL
110 120 130 140 150
LDEKKAYYCF ATPDELEESR QLQIKQGVQP KYNRKWLPED MGGSMPQSEI
160 170 180 190 200
QKRLDAGEPC VIRMKIPDHT RIRHDDIIRG IVWFDSSTVD DQVLMKSDGF
210 220 230 240 250
PTYHLASVVD DHLMNITHVI RGEEWLSSTP KHLLLYDFFG WEKPEFAHLP
260 270 280 290 300
LLLNPDRSKL SKRQGDVAVE DYMAKGYSKD ALVNFVALLG WNEGEGVEQE
310 320 330 340 350
VYSMNELIEK FTLEKVGKSG AVFNVEKLNW IQKQHLKLVS HEDLAKQAKA
360 370 380 390 400
ILVEKLKERE SMMPSEKITD DAYLLNVVEL MHDRVNFVHE FVTFSEYFFF
410 420 430 440 450
EPEAYEEAAI KKRWKENTND LLSEFKGILA GLDNFNSAAI EEALAKYAEL
460 470 480 490 500
KGVKNAALIH PIRLAVSGVS FGPSLYHLME VIGKEACLRR IERAVDKLDY

QEA
Length:503
Mass (Da):57,584
Last modified:September 2, 2008 - v1
Checksum:iD620D74DFFFBC062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001100 Genomic DNA Translation: ACF15134.1
RefSeqiWP_012501216.1, NC_011026.1

Genome annotation databases

EnsemblBacteriaiACF15134; ACF15134; Ctha_2685
KEGGicts:Ctha_2685

Similar proteinsi

Entry informationi

Entry nameiSYE_CHLT3
AccessioniPrimary (citable) accession number: B3QYR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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