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Protein

NAD kinase

Gene

nadK

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Proton acceptorUniRule annotation1
Binding sitei165NADUniRule annotation1
Binding sitei167NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 67NADUniRule annotation2
Nucleotide bindingi137 – 138NADUniRule annotation2
Nucleotide bindingi178 – 183NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTHA517418:G1GC9-1179-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Ctha_1131
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
Proteomesi
  • UP000001208 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208421 – 283NAD kinaseAdd BLAST283

Proteomic databases

PRIDEiB3QYG7

Interactioni

Protein-protein interaction databases

STRINGi517418.Ctha_1131

Structurei

3D structure databases

SMRiB3QYG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B3QYG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFGIVVNTN RPRAIAAGKE LISWMRKEQI DFVLDANSAE NLKESPSVEM
60 70 80 90 100
ENMHEQADFF VSLGGDGTLL GVSHFSNTKP IIGINLGRLG FLAEFCEHEM
110 120 130 140 150
YDVIKRVLQN NFMLENRTQL EVSVSGKGQV RNFTGLNDVV IEKGTYPGVP
160 170 180 190 200
VISVSIDNNL VSEYRADGVI IATSTGSTGY SLSAGGPIII PKSKVFVVTP
210 220 230 240 250
VCPHMLTVRP MVICDDKEIE VRVETPGDRF VLNCDGMLIQ NISPSHQIRV
260 270 280
RKAKNTVNLI ANERRNYYNV LRQKFHWGKE QES
Length:283
Mass (Da):31,542
Last modified:September 2, 2008 - v1
Checksum:i2B40ED1DEAD59ACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001100 Genomic DNA Translation: ACF13595.1
RefSeqiWP_012499679.1, NC_011026.1

Genome annotation databases

EnsemblBacteriaiACF13595; ACF13595; Ctha_1131
KEGGicts:Ctha_1131

Similar proteinsi

Entry informationi

Entry nameiNADK_CHLT3
AccessioniPrimary (citable) accession number: B3QYG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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