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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59S-adenosyl-L-methionineUniRule annotation1
Binding sitei84S-adenosyl-L-methionineUniRule annotation1
Binding sitei111S-adenosyl-L-methionineUniRule annotation1
Binding sitei169SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCTHA517418:G1GC9-1124-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Ctha_1077
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
Proteomesi
  • UP000001208 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003879451 – 226tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST226

Interactioni

Protein-protein interaction databases

STRINGi517418.Ctha_1077

Structurei

3D structure databases

ProteinModelPortaliB3QY13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RBY Bacteria
COG0220 LUCA
HOGENOMiHOG000033410
KOiK03439
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

B3QY13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGRGRHPS RLKVKPPEPE ILAKYLHHWN TKELYHHPDT FLQVSSPSFF
60 70 80 90 100
QNENPLEIDI GCATGDLVCS LAQKNPQVNF IGVEVSMKPL YRAIKYSVRE
110 120 130 140 150
QIENVRFIKT DFRLLYPLLP DASVQKIFFH FPVPVVRAKD SKYLIFSEDF
160 170 180 190 200
LSEMHRALQV GGMISVISDS AEYFPIMREL GQNDTRYELI SDEAKCMALE
210 220
PDEKSYYHKY WDAQGREKFR FILVKK
Length:226
Mass (Da):26,347
Last modified:September 2, 2008 - v1
Checksum:i083F6497D7B47BBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001100 Genomic DNA Translation: ACF13541.1
RefSeqiWP_012499625.1, NC_011026.1

Genome annotation databases

EnsemblBacteriaiACF13541; ACF13541; Ctha_1077
KEGGicts:Ctha_1077

Entry informationi

Entry nameiTRMB_CHLT3
AccessioniPrimary (citable) accession number: B3QY13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 2, 2008
Last modified: February 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome